revu alexander (4 Ergebnisse)

Zustand: New.

Taschenbuch. Zustand: Neu. Neuware -This thesis aims at elucidating the essential role played by the urokinase receptor (uPAR) in driving VEGF induced angiogenesis. On the molecular level the formation of blood vessels from preexisting ones requires the coordinated interaction of the protease system which by their degradation of the extracellular matrix facilitates the adhesion receptors of endothelial cells to invoke migration and invasion. Using flow cytometry and immunohistochemistry based techniques we show that the protease receptor uPAR through its interaction with alpha5beta1 integrins funnels VEGF induced signals for angiogenesis. Inhibition of uPAR interaction with integrins not only impedes endothelial cell migration but also in vivo VEGF induced angiogenesis. In effect uPAR could be investigated as a potential target for angiogenesis based drug therapies.Books on Demand GmbH, Überseering 33, 22297 Hamburg 88 pp. Englisch.

Couverture rigide. Zustand: bon. RO80094884: 1927. In-16. Relié. Bon état, Couv. convenable, Dos satisfaisant, Quelques rousseurs. 809 (+ 197) + 837 ( + 189) + 948 (+ 77) pages. Dos des tomes 1 et 2 légèrement effacés. . . . Classification Dewey : 400-LANGUES.

Zustand: Fair. Reliure solide et en bon état des rousseurs laissant une lecture très satisfaisante. in-12. 1877. relié. 864 pages. Fort in-12 (122x175 mm) 864 pp.; Exemplaire relié cuir noir dos à quatre faux-nerfs; Deuxième édition augmentée d'un nouveau supplément; Reliure solide et en bon état des rousseurs laissant une lecture très satisfaisante. Fair.