podack eckhard (13 Ergebnisse)

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

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Paperback. Zustand: Brand New. reprint edition. 127 pages. 9.60x6.60x0.40 inches. In Stock.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - InhaltsangabeGranule-Mediated Cytolysis of Target Cells.- Structure and Function of Perforin.- Structure and Function of C8 in the Membrane Attack Sequence of Complement.- Granzymes: a Family of Serine Proteases in Granules of Cytolytic T Lymphocytes.- The Molecular Mechanism of Complement C9 Insertion and Polymerisation in Biological Membranes.- The Isolation and Characterization of Two Cytotoxic T-Lymphocyte-Specific Serine Protease Genes.- A Serine Protease-Encoding Gene That Marks Activated Cytotoxic T Cells In Vivo and In Vitro.- Structure and Function of the Family of Proteoglycans That Reside in the Secretory Granules of Natural Killer Cells and Other Effector Cells of the Immune Response.- The Homologous Species Restriction of the Complement Attack: Structure and Function of the C8 Binding Protein.

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Zustand: Used. pp. 272.

Taschenbuch. Zustand: Neu. Advances in Tumor Immunology and Immunotherapy | Joseph D. Rosenblatt (u. a.) | Taschenbuch | ix | Englisch | 2016 | Humana | EAN 9781493950973 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Paperback. Zustand: Brand New. reprint edition. 380 pages. 9.25x6.10x1.06 inches. In Stock.

Hardcover. Zustand: Brand New. 1st edition. 371 pages. 9.25x6.25x1.00 inches. In Stock.

Zustand: New.