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Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: New. pp. 548.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: New.

Hardcover. Zustand: Brand New. 1st edition. 548 pages. 9.30x6.30x1.30 inches. In Stock.

Buch. Zustand: Neu. Neuware - G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.…

Paperback. Zustand: Good. pp. 234 / illustrated by Villon, Gimond, Grüber, Marchand, Despierre, brassaï, Gischia, uncut pages/onopengesneden French.

1945. Paris Éditions de La Table Ronde 1945 - Broché couv. rempliée 25 5 cm x28 5 cm 227 pages - Exemplaire n° 1993 un des 2000 sur Vélin Crèvecoeur des papeteries du Marais - Texte collectif - Au sommaire : Jean RACINE : Principes de La Tragédie tirés de la Poétique d' Aristote - André SUARES avec Maïa - Jules ROMAINS : Nomentanus Le Réfugié - Daniel HALEVY : Nouveau Discours sur L'Histoire Universelle - Marcel AYME : Samson - Philippe HERIAT : Les Amours Bourgeoises - Patrice de LA TOUR DU PIN : Poèmes d'enfants - Pierre BOUTANG : Chez Madame Dorlinde - DESSINS de : Jacques VILLON Marcel GIMOND Francis GRÜBER André MARCHAND Jacques DESPIERRE BRASSAÏ Léon GISCHIA - Cet ouvrage se termine par un Fac-simile d'une lettre de LOUIS XIII au CARDINAL de RICHELIEU - Textes réunis par Thierry MAULNIER -- En partie non coupé - Très bon état. Bon état.…

Textes réunis par Thierry Maulnier. Exemplaire numéroté sur vélin crème du Marais. Dos restauré. [16573].