P ramkumar (58 Ergebnisse)

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Zustand: Hervorragend. Zustand: Hervorragend | Seiten: 528 | Sprache: Englisch | Produktart: Bücher | This book contains high-quality papers presented in the conference Recent Advances in Mechanical Infrastructure (ICRAM 2020) held at IITRAM, Ahmedabad, India, from 21-23 August 2020. The topics covered in this book are recent advances in thermal infrastructure, manufacturing infrastructure and infrastructure planning and design.…

Zustand: New. Details several different aspects of the cochlear inflammatory processDiscusses recent clinical trials focusing on the use of anti-inflammatory agents for the treatment of drug, noise-induced and auto-immune mediated hearing loss.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatmentof hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of theoxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.…

Taschenbuch. Zustand: Neu. Inflammatory Mechanisms in Mediating Hearing Loss | Vickram Ramkumar (u. a.) | Taschenbuch | x | Englisch | 2019 | Springer | EAN 9783030064471 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

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Taschenbuch. Zustand: Neu. Tribology in Materials and Applications | Jitendra Kumar Katiyar (u. a.) | Taschenbuch | Materials Forming, Machining and Tribology | xiii | Englisch | 2021 | Springer | EAN 9783030474539 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Taschenbuch. Zustand: Neu. Recent Advances in Materials Technologies | Select Proceedings of ICEMT 2021 | K. Rajkumar (u. a.) | Taschenbuch | Lecture Notes in Mechanical Engineering | xxvi | Englisch | 2022 | Springer | EAN 9789811938948 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Taschenbuch. Zustand: Neu. Advances in Simulation, Product Design and Development | Proceedings of AIMTDR 2021 | P. K. Jain (u. a.) | Taschenbuch | Lecture Notes in Mechanical Engineering | xviii | Englisch | 2022 | Springer | EAN 9789811945557 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Taschenbuch. Zustand: Neu. Trends in Mechanical and Biomedical Design | Select Proceedings of ICMechD 2019 | Esther Titilayo Akinlabi (u. a.) | Taschenbuch | Lecture Notes in Mechanical Engineering | xvi | Englisch | 2020 | Springer | EAN 9789811544873 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book presents select proceedings of the 8th International and 29th All India Manufacturing Technology, Design and Research Conference (AIMTDR 2021). It covers the recent developments in the areas of product design and development, computer-aided design, computer-aided manufacturing, computer-aided engineering, reverse engineering, modelling and simulation of manufacturing systems, simulation of manufacturing processes, vibration analysis, machine tool design and development, optimization techniques, etc. The contents of this book will be useful for students, researchers and as well as industry professionals in the various fields of mechanical engineering.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book contains high-quality papers presented in the conferenceRecent Advances in Mechanical Infrastructure (ICRAM 2020) held at IITRAM, Ahmedabad, India, from 21-23 August 2020. The topics covered in this book are recent advances in thermal infrastructure, manufacturing infrastructure and infrastructure planning and design.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book broadens the knowledge of tribology. This book is evolved out of current research trends on tribological performance of systems related to nano tribology, rheology, engines, polymer brushes, composite materials, erosive wear and lubrication. The book deals with enhancing the ideas on tribological properties, the different types of wear phenomenon and lubrication enhancement. Further, the tribological performance of systems, whether nano, micro or macro-scale, depends upon a large number of external parameters and important among them are temperature, contact pressure and relative speed. Thus, the book focus on the theoretical aspects to industrial applications of tribology.…

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book contains high-quality papers presented in the conferenceRecent Advances in Mechanical Infrastructure (ICRAM 2020) held at IITRAM, Ahmedabad, India, from 21-23 August 2020. The topics covered in this book are recent advances in thermal infrastructure, manufacturing infrastructure and infrastructure planning and design.…

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book broadens the knowledge of tribology. This book is evolved out of current research trends on tribological performance of systems related to nano tribology, rheology, engines, polymer brushes, composite materials, erosive wear and lubrication. The book deals with enhancing the ideas on tribological properties, the different types of wear phenomenon and lubrication enhancement. Further, the tribological performance of systems, whether nano, micro or macro-scale, depends upon a large number of external parameters and important among them are temperature, contact pressure and relative speed. Thus, the book focus on the theoretical aspects to industrial applications of tribology. …

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The book contains high quality papers presented in conferenceRecent Advances in Mechanical Infrastructure (ICRAM-2019) held at IITRAM, Ahmedabad, India from 20-21 April, 2019.The topics covered in this book are recent advances in thermal infrastructure, manufacturing infrastructure and infrastructure planning and design.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book presents the select proceedings of the first International Conference on Energy and Materials Technologies (ICEMT) 2021, organized by the Department of Mechanical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, India. It covers the recent technologies in two broad thematic areas: energy and materials. Various topics covered in this book include advanced materials and characterization, mechanical behavior of materials, nanomaterials and nanotechnology, biomaterials, composite materials, environmental-friendly materials, structural materials, advances in aerospace technology, and advanced materials and manufacturing. The book is useful for students, researchers, and professionals in the area of mechanical engineering, especially various domains of materials.…