mendell jerry (13 Ergebnisse)

Zustand: Very Good. Very Good condition. A copy that may have a few cosmetic defects. May also contain light spine creasing or a few markings such as an owner's name, short gifter's inscription or light stamp.

Zustand: Good. Former library copy. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Includes library markings. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.

Zustand: Good. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.

Zustand: Good. Former library copy. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Includes library markings. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.

2nd Edition. xvi, 811 p. Hardcover. 2nd Edition. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Sprache: Englisch.

Hardcover. Zustand: Gut. XXII, 434 p.: Ill. Aus dem Vorbesitz von Peter Frommelt: Facharzt für Neurologie und Psychiatrie, Psychotherapie und für Physikalische und Rehabilitative Medizin; 1988-2011 Chefarzt der Abteilung für Neurologische und Neuropsychologische Rehabilitation der Asklepios-Klinik Schaufling/Deggendorf, 2013 Helmut-Bauer Preis der Deutschen Gesellschaft für Neurologie und der Deutschen Gesellschaft für Neurorehabilitation. - Einband leicht berieben, mit getrocknetem Wasserschaden, daher viele Seiten etwas gewellt, Ex Libris Frommelt im Vorsatz / Binding slightly rubbed, with dried water damage, therefore many pages somewhat curled, ex libris Frommelt in endpaper. - CONTENTS Part I. Approach to the Patient with Muscle Disease 1. STRUCTURE AND FUNCTION OF NORMAL MUSCLE THE MOTOR UNIT MUSCLE FIBER TYPES Neural Control of Muscle Fiber Type Activation of Motor Units According to Muscle Fiber Type VOLUNTARY CONTROL OF MOTOR UNIT ACTIVITY Relationship of Size to the Recruitment of Single Motor Units Firing Rates of Single Motor Units Impaired Voluntary Control of Motor Units MECHANISMS OF MUSCULAR CONTRACTION Biochemistry of Contraction The Sliding Filament Theory Excitation-Contraction Coupling CYTOSKELETON SUMMARY OF MUSCLE FUNCTION: RELATIONSHIP TO MYOPATHIES 2. EVALUATION OF THE PATIENT WITH MYOPATHY DEFINITION OF MYOPATHY The Hereditary Myopathies The Inflammatory Myopathies Myopathies Due to Systemic Diseases CLINICAL EVALUATION History Examination DIFFERENTIAL DIAGNOSIS Disorders Presenting at Birth with Hypotonia Disorders Presenting in Infancy Disorders Presenting in Childhood with Progressive Proximal Weakness Disorders Presenting in Adulthood LABORATORY EVALUATION Blood Studies Urine Studies Muscle Imaging Procedures ELECTRODIAGNOSIS The Technique of Electromyography Abnormal Spontaneous Activity Voluntary Activity Quantitative Electromyography Electrical Stimulation Tests: Nerve Conduction Studies MUSCLE BIOPSY Indications for Biopsy Selection of Biopsy Sites Tissue Removal and Preparation Histologic Techniques Differentiating Neuropathy from Myopathy Preferential Fiber Type Involvement Sources of Diagnostic Error NERVE BIOPSY Indications for Biopsy Selection of Biopsy Sites Tissue Removal and Preparation 3. GENETIC EVALUATION OF THE PATIENT AND FAMILY CLINICAL EVALUATION APPLICATION OF RECOMBINANT DNA TECHNOLOGY Patient and Family Sampling Probes for DNA Analysis Southern Blotting Polymerase Chain Reaction USE OF GENETIC INFORMATION FOR DIAGNOSIS Detection of Disease Genes Carrier Detection and Prenatal Diagnosis Linkage Analysis Part II. Specific Myopathies 4. THE MUSCULAR DYSTROPHIES DYSTROPHIN-DEFICIENT DYSTROPHIES Duchenne Muscular Dystrophy Becker Muscular Dystrophy Phenotypic Variations of Dystrophin Deficiency. Genetics of Duchenne and Becker Muscular Dystrophies Treatment EMERY-DREIFUSS MUSCULAR DYSTROPHY Clinical Features Laboratory Features Genetics Treatment MYOTONIC MUSCULAR DYSTROPHY Clinical Features Congenital Myotonic Dystrophy Laboratory Features Genetics Treatment FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY Clinical Features Laboratory Features Genetics Treatment SCAPULOPERONEAL SYNDROMES Muscular Dystrophy with Scapuloperoneal Distribution Spinal Muscular Atrophy with Scapuloperoneal Distribution Peripheral Neuropathy with Scapuloperoneal Distribution (Davidenkow's Syndrome) LIMB-GIRDLE DYSTROPHY Clinical Features Laboratory Features Genetics Treatment OCULOPHARYNGEAL MUSCULAR DYSTROPHY Clinical Features Laboratory Features Genetics Treatment CONGENITAL MUSCULAR DYSTROPHY Congenital Muscular Dystrophy without Cerebral Involvement Congenital Muscular Dystrophy with Cerebral Involvement Treatment DISTAL MYOPATHIES Welander Myopathy (Late-Adult-OnsetType I) Late-Onset Distal Myopathy Type II (Markesbery) Early-Adult-Onset Distal Myopathy 5. INFLAMMATORY MYOPATHIES DERMATOMYOSITIS Clinical Features Laboratory Features Management Pathogenesis POLYMYOSITIS Clinical Features Laboratory Features Differential Diagnosis Distinguishing Polymyalgia Rheumatica from Polymyositis Management Pathogenesis INCLUSION BODY MYOSITIS Clinical Features Laboratory Features Treatment Pathogenesis MYOPATHIES ASSOCIATED WITH OTHER CONNECTIVE-TISSUE DISEASES Mixed Connective-Tissue Disease Progressive Systemic Sclerosis Systemic Lupus Erythematosus Rheumatoid Arthritis Sjogren's Syndrome Polyarteritis Nodosa and Other Forms of Systemic Vasculitis Behcet's Syndrome GIANT-CELL AND GRANULOMATOUS MYOSITIS Giant-Cell Myositis Sarcoidosis Inflammatory Bowel Disease EOSINOPHILIC SYNDROMES AND MYOSITIS Eosinophilic Polymyositis Diffuse Fasciitis with Eosinophilia (Shulman's Syndrome) Eosinophilia-Myalgia Syndrome Associated with Tryptophan Toxic-Oil Syndrome MYOSITIS AND MYOPATHIES CAUSED BY INFECTIOUS AGENTS Viral Infections Protozoa Helminths Lyme Disease Bacterial Infections Fungal Infection GRAFT VERSUS HOST DISEASE 6. CONGENITAL MYOPATHIES DEFINITION OF CONGENITAL MYOPATHY PRESENTATION OF A PATIENT WITH CONGENITAL MYOPATHY Differential Diagnosis of Floppy Infant Clinical and Laboratory Features of Congenital Myopathies COMMON TYPES OF CONGENITAL MYOPATHIES. Central Core Disease Nemaline Myopathy Centronuclear Myopathy UNCOMMON TYPES OF CONGENITAL MYOPATHIES Multicore Disease Fingerprint Body Myopathy Sarcotubular Myopathy Hyaline Body Myopathy (Familial Myopathy with Probable Lysis of Myofibrils) DUBIOUS TYPES OF CONGENITAL MYOPATHIES. Congenital Fiber-Type Disproportion Reducing Body Myopathy Cytoplasmic (Spheroid) Body Myopathy Myopathy with Tubular Aggregates Zebra Body Myopathy Trilaminar Myopathy Other Rare, Morphologically Distinct Myopathies. 7. METABOLIC MYOPATHIES ENERGY METABOLISM IN EXERCISING MUSCLE Glycogen Metabolism t Lipid Metabolism Other Sources of Energy EVALUATION OF THE PATIENT Clinical Features Laboratory Findings DEFECTS OF GLYCOGEN METABOLISM Disorders Producing Dynamic Symptoms (Exercise Intolerance) Disorders Producing Static Symptoms (Fixed Weakness) DEFECTS OF LIPID METABOLISM.

Hardcover. Zustand: Very Good. 2. Auflage. unread, cover with shelfwear or minor damages.

Zustand: New. pp. 720 Illus.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.

Buch. Zustand: Neu. Neuware -About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 828 pp. Englisch.

Hardcover. Zustand: Brand New. 2nd edition. 811 pages. 9.75x6.50x1.75 inches. In Stock.

Zustand: New.

Hardcover. Zustand: Brand New. 1st edition. 695 pages. 10.25x7.25x1.25 inches. In Stock.