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Zustand: Good. Volume 7. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,750grams, ISBN:9780306450266. …

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

Zustand: New. In English.

Hardcover. Zustand: Brand New. 1st edition. 443 pages. 9.75x6.75x1.00 inches. In Stock.

Zustand: New. In English.

Zustand: New. In English.

Zustand: New. pp. 384 52:B&W 6.14 x 9.21in or 234 x 156mm (Royal 8vo) Case Laminate on White w/Gloss Lam.

Buch. Zustand: Neu. Neuware - This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy. Enables researchers to better detect, measure, and characterize aggregates and particles during protein drug developmentFeaturing contributions from leading pharmaceutical investigators around the world, this text enables researchers to choose the most appropriate analytical methods in order to detect and characterize the full spectrum of protein aggregates and particles that can be present in a protein pharmaceutical. Moreover, the authors provide detailed examples of how these methods can be applied during both process and formulation development, helping researchers better manage the problem of protein instability as they seek to develop protein drugs.The text begins with an introduction to aggregates and particles, focusing on their potential immunogenicity. Next, it covers:Methods to detect and measure soluble aggregates based on separation, light scattering, and new technologyMethods to detect and measure insoluble aggregates and both sub-visible and visible particlesSpectroscopic techniques such as UV/VIS, fluorescence, infrared and Raman spectroscopy, and microscopy to characterize aggregates and particles, elucidate their structures, and identify proteinaceous and non-proteinaceous particlesComparative advantages and disadvantages of the methods for protein aggregate analysisApproaches for managing aggregates and particles found during protein purification and formulation developmentThroughout the text, case studies help researchers deal with the challenges that arise in detecting and analyzing protein aggregates and particles.Protein pharmaceuticals are increasingly used to treat life-threatening and chronic diseases, including cancer, viral infections, metabolic disorders, and central nervous system diseases. With Analysis of Aggregates and Particles in Protein Pharmaceuticals as their guide, pharmaceutical researchers now have an important tool in overcoming the challenging problem of aggregates and particles in protein drug development.…

Taschenbuch. Zustand: Neu. Physical Methods to Characterize Pharmaceutical Proteins | James N. Herron (u. a.) | Taschenbuch | xviii | Englisch | 2013 | Springer US | EAN 9781489910813 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from 'traditional' low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca demic environments, forcing pharmaceutical scientists to explore a domain previ ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad ministration have been examined for proteins, no real, generally applicable alter native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs. …

Buch. Zustand: Neu. Analysis of Aggregates and Particles in Protein Pharmaceuticals | H-C Mahler | Buch | Contributors ixPreface xiiiGlossary xv1 The Critical Need for Robust Assays for Quantitation and Characterization of Aggregates of Therapeutic Proteins 1John F. Carpenter | Englisch | 2012 | John Wiley & Sons Inc | EAN 9780470497180 | Verantwortliche Person für die EU: Libri GmbH, Europaallee 1, 36244 Bad Hersfeld, gpsr[at]libri[dot]de | Anbieter: preigu.…

Zustand: New. In English.

Hardcover. Zustand: Brand New. 1st edition. 678 pages. 10.75x7.50x1.50 inches. In Stock.

Gebundene Ausgabe. Zustand: Wie neu. 464 Seiten; Buchdeckel minimal berieben/bestossen. Innenteil tadellos - u n g e l e s e n - keine Risse, Knicke, Anmerkungen. ! Altersbedingt minimal nachgedunkelt! KEIN Mängelexemplar! Versand aus München V1262 Sprache: Deutsch Gewicht in Gramm: 798.