Issinger olaf georg (13 Ergebnisse)
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Protein Kinase Ck2: From Structure to Regulation
Ahmed, Khalil (Editor)/ Allende, J. E. (Editor)/ Issinger, Olaf-georg (Editor)
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Taschenbuch. Zustand: Neu. Protein Kinase CK2 - From Structure to Regulation | Khalil Ahmed (u. a.) | Taschenbuch | v | Englisch | 2013 | Springer US | EAN 9781461356967 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer, 2015
Serie: Buch 9 von 25 - Advances in Biochemistry in Health and Disease
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is a…lso the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the… recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.
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Sprache: Englisch
Verlag: Springer International Publishing, 2016
Serie: Buch 9 von 25 - Advances in Biochemistry in Health and Disease
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in al…l cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
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Sprache: Englisch
Verlag: Springer International Publishing, 2015
Serie: Buch 9 von 25 - Advances in Biochemistry in Health and Disease
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cance…rs examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
Protein Kinase CK2 Cellular Function in Normal and Disease States
Ahmed, Khalil (Edited by)/ Issinger, Olaf-Georg (Edited by)/ Szyszka, Ryszard (Edited by)
Sprache: Englisch
Verlag: Springer, 2015
Serie: Buch 9 von 25 - Advances in Biochemistry in Health and Disease
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Hardcover. Zustand: Brand New. 1st edition. 378 pages. 9.25x6.25x1.00 inches. In Stock.
Protein Kinase Ck2 Cellular Function in Normal and Disease States (Advances in Biochemistry in Health and Disease)
Ahmed, Khalil (Editor) / Issinger, Olaf-Georg (Editor) / Szyszka, Ryszard (Editor)
Sprache: Englisch
Verlag: Springer, 2016
Serie: Buch 9 von 25 - Advances in Biochemistry in Health and Disease
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A Molecular and Cellular View of Protein Kinase CK2
Ahmed, Khalil (Edited by)/ Chambaz, E. (Edited by)/ Issinger, Olaf-Georg (Edited by)
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Paperback. Zustand: Brand New. reprint edition. 242 pages. 11.00x8.26x0.59 inches. In Stock.
