hossain mohammad zulfiquer (3 Ergebnisse)

Taschenbuch. Zustand: Wie neu. 196 Seiten; Zustand geprüft, Versand werktags innerhalb von 24 Stunden. neuwertig und ungelesen ZA 9105047 Sprache: Englisch Gewicht in Gramm: 295.

Taschenbuch. Zustand: Neu. ¿-Catenin, TCF, and ICAT | Novel Roles in T Cell Development, Function, and Aging | Mohammad Zulfiquer Hossain | Taschenbuch | 196 S. | Englisch | 2009 | LAP LAMBERT Academic Publishing | EAN 9783838334509 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Neuware -In addition to working together to drive expression of target genes, ¿-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ¿-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ¿-catenin-TCF interactions, in the T cell lineage. We found that ¿-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ¿-catenin-TCF interactions in normal thymic involution. We also discovered that ¿-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ¿-catenin. This study, thus, provides novel insights into the role of ¿-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.Books on Demand GmbH, Überseering 33, 22297 Hamburg 196 pp. Englisch.