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Paperback. Zustand: Brand New. 60 pages. French language. 8.66x5.91x0.16 inches. In Stock.

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Taschenbuch. Zustand: Neu. Neuware -Many peptides by their molecular metabolism in the thyroid gland cell are involved: mutations of the TSH receptor are a source of TSH resistance with congenital hypothyroidism. A new oroxigenic peptide, Ghrelin, is diffused in the body and with tachykinin another new paracrine endocrine factor peptide; PTTG and FGF-2 are prognostic markers of differentiated thyroid cancers; CRIF1 is a new core protein that interacts with Gadd45 and may play a role in the negative regulation of the cell cycle of progression and growth ; protooncongenic RET mutations have become the marker of medullary thyroid cancer supplanting calcitonin to which should be added CGRP, CGRP¿ and amylin; regulatory proteins binding cyclic AMP, G protein, Gi alpha 1, MAL proteolipid protein are identified alongside immunological antigens active in Basedow's disease, autoimmune polyendocrinopathies.These peptides, by the diversity of their function, argue in favour of the medical science concept of equivalent general endocrinology.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Iodine regulates nutritional metabolism probably via the microbiota. Thyrodiabetes has been of concern to clinicians. The endocrine disruptors came to remind us if need be that the thyroid gland is a sentinel of the environment which according to our approach testifies to the primordial role of mineral iodine in most living organisms. General conclusion : The Basténie classification is a bioclinical semiology which could be reviewed by integrating obesity as an incipiens stage of the epigenetic thyroid turn over of the deiodase realizing an inactive TSH. Primary hypothyroidism from a historical-technical point of view has been recognized since Bastenia:1 myxedema by thyroid atrophy with low T4 and T3 and high TSH.2 crude hypothyroidism or only elevated TSH.3 subclinical hypothyroidism or only TRH test is positive.4 thyroiditis or only autoantibodies exist 5 or turn over of the deiodase is involved.These are the perspectives of a practitioner in the medical clinic ward and endocrine diseases.Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Although the enzyme immunoassay technique we used is the first generation, our study remains important (25, 26, 27). Indeed, our work on 52 patients using 92 HRT tests with levothyroxine and levothyroxine and triiodothyronine combination allowed us to evaluate optimal hormonal balance. The dose placing the TSH delta in a zone of known euthyroidism, (4 to 20 micro IU/ml (IRMA)) was found to be 111.84 + 31.33 microg/d; 72.75 + 7.5 microg/m /d; 1.84 + 0.53 microg/kg/d. However, even when delta TSH is less than 4 micro IU/ml (1.03 + 1.47 micro IU/ml) under levothyroxine or levothyroxine and triiodothyronine combination (1.06 + 1.13 micro IU/ml) without any significant difference between the delta TSH means of these two groups, we found no change in cholesterol or heart rate apart from a weak negative correlation (r : 0.105) between heart rate and delta TSH of less than 4 micro IU/ml when levothyroxine and triiodothyronine were combined.Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch.

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Taschenbuch. Zustand: Neu. RESEARCH REPORT FOUNDATION RECIPIENTS LEOPOLD SEDAR SENGHOR | El Hassane Sidibé | Taschenbuch | 68 S. | Englisch | 2020 | Sciencia Scripts | EAN 9786200920508 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. SOCIAL-POLITICAL CLINICAL MOLECULE. [PRECISE IODINE MEDICINE] | SOCIAL DEMOCRACY | El Hassane Sidibé (u. a.) | Taschenbuch | 68 S. | Englisch | 2020 | Sciencia Scripts | EAN 9786200882226 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Neuware -Nephropathy in the diabetic patient follows a well-established course, beginning with microalbuminuria, progressing to proteinuria, hyperazotemia and culminating in end-stage renal failure. Early nephropathy has also been shown to predict vision-threatening retinal disease in patients with type 1 diabetes. Chronic hyperglycemia is a key factor in microangiopathy because of its rate, duration and likely mediators. The hypothesis of a relationship between the angiotensin-1 converting enzyme gene and the deleterious effects of chronic hyperglycemia is possible through an insertion/deletion polymorphism which in fact influences the frequency of serious cardiac complications in insulin-dependent patients with diabetic nephropathy, a situation characterized by high plasma angiotensin converting enzyme concentrations. This chronic hyperglycemia is related to the poorly understood angiotensin II. Experimentally, growth hormone and insulin like-growth factors, through a complex system, may be responsible for the changes.Books on Demand GmbH, Überseering 33, 22297 Hamburg 104 pp. Englisch.

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Taschenbuch. Zustand: Neu. Neuware -Since the introduction of third generation of the TSH assay methods, TRH test remains only essential for limited domains. But for some authors, application of immunoradiometric assays combined with TRH test have not sufficiently evaluated as remarked by some authors. Thyreotroph cell has a potent desiodase and active in normal subject explaining the strong correlation between T4 and TSH. Interindividual variability of the activity of desiodase enzyme is very possible because of genetic polymorphism. We have studied prospectively and determined in and homogenous patients population with treated primary hypothyroidism, a real overdosage by an abolished first generation immunoradiometric TSH to TRH and given optimal dosage of levothyroxine during substitutive thyroid hormono-therapy. Our criterias for TSH reponse to TRH had for lower limite a delta TSH of 4 UI/ml, this is higher than lower level of 1 UI/ml proposed by some authors. TRH tests as other dynamic assays of anterior pituitary are useful to amplify subtle abnormalities. A defect in reponse to hypothalamic hormone can be caused by absence or dysfunction of pituitary cells.Books on Demand GmbH, Überseering 33, 22297 Hamburg 76 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Many peptides by their cell molecular metabolism in the thyroid gland are involved : mutations of TSH receptor is linked to hormone resistance with congenital hypothyroidism. ; a new oroxigenic peptide, Ghrelin is widespread in endocrine tissues ; tachykinine is another novel peptide with endocrine paracrine effect. PTTG and FGF-2 are prognostic markers of differentiated cancers ; CRIF1 is a novel protein of nucleus interacting with Gadd45 and could negatively regulate cycle cell progression and cell growth ; mutations of RET protooncogene is now the best CMT biomarker in the place of calcitonin in addition with CGRP¿, CGRP¿ and Amylin ; regulating proteins of CAMP, protein G, Gi alpha 1, MAL proteolipid are identified near immunologic antigens involved in Grave¿s disease, autoimmune polyendocrinopathies.These peptides by their diversity of function support the concept of general endocrinology equivalent of medical sciences.Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch.

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Taschenbuch. Zustand: Neu. Neuware -The association between diabetes and myxedema, reported as early as 1895 by Exald and quoted by Ducros, has long appeared to be fortuitous. Since the recent refinement of the means of thyroid exploration, the epidemiology of hypothyroidism has been marked by an increasing frequency, especially in the female sex and in the elderly. Elsewhere, it is rarely described. Thus, according to Trowell, apart from one case, no primary form was observed before 1960 in Africa. We found a potential abnormality of glucose tolerance in one case. Diabetes It is non-insulin dependent and of plethoric type in the 3 cases. In 2 cases, diabetes was posterior and revealed by cardinal signs such as polyuria and polydipsia. On the other hand, in the last case, diabetes was present 5 years before hypothyroidism; it was detected systematically when a buttock abscess was discovered in a genetically predisposed subject who had not had any signs of hypothyroidism until then.Books on Demand GmbH, Überseering 33, 22297 Hamburg 80 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Since the introduction of 3rd generation TSH assay methods, TRH testing remains essential only in a few limited areas. However, for these same authors, the application of ultrasensitive tests in conjunction with the TRH test has not yet been fully evaluated as some authors note. The thyroid cell has a potent and active deiodase in the normal subject explaining the strong correlation between T4 and TSH. An inter-individual variability of the activity of this deiodase enzyme is very conceivable considering the genetic polymorphism. We prospectively studied and determined in a homogeneous population of patients with treated peripheral hypothyroidism, a real overdose by an abolished response of the immunoradiometric TSH of first generation, to TRH and specify the optimal doses of levothyroxine (LT4) in this thyroid hormone replacement therapyBooks on Demand GmbH, Überseering 33, 22297 Hamburg 96 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Many peptides by their cell molecular metabolism in the thyroid gland are involved : mutations of TSH receptor is linked to hormone resistance with congenital hypothyroidism. ; a new oroxigenic peptide, Ghrelin is widespread in endocrine tissues ; tachykinine is another novel peptide with endocrine paracrine effect. PTTG and FGF-2 are prognostic markers of differentiated cancers ; CRIF1 is a novel protein of nucleus interacting with Gadd45 and could negatively regulate cycle cell progression and cell growth ; mutations of RET protooncogene is now the best CMT biomarker in the place of calcitonin in addition with CGRP, CGRP¿ and Amylin ; regulating proteins of CAMP, protein G, Gi alpha 1, MAL proteolipid are identified near immunologic antigens involved in Grave¿s disease, autoimmune polyendocrinopathies.These peptides by their diversity of function support the concept of general endocrinology equivalent of medical sciences.Books on Demand GmbH, Überseering 33, 22297 Hamburg 104 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Muchos péptidos por su metabolismo molecular en la célula de la glándula tiroides están involucrados: las mutaciones del receptor de la TSH son una fuente de resistencia a la TSH con el hipotiroidismo congénito. Un nuevo péptido oroxigénico, la grelina, se difunde en el cuerpo y con la taquicinina otro nuevo péptido de factor endocrino paracrino; PTTG y FGF-2 son marcadores pronósticos de cánceres diferenciados de tiroides; CRIF1 es una nueva proteína central que interactúa con Gadd45 y puede desempeñar un papel en la regulación negativa del ciclo celular de progresión y crecimiento ; Las mutaciones protooncongénicas RET se han convertido en el marcador del cáncer medular de tiroides que suplanta a la calcitonina a la que hay que añadir CGRP, CGRP¿ y amilina; se identifican proteínas reguladoras que unen el AMP cíclico, la proteína G, el Gi alfa 1, la proteína proteolípida MAL, junto con antígenos inmunológicos activos en la enfermedad de Basedow, las poliedrocrinopatías autoinmunes.Estos péptidos, por la diversidad de su función, argumentan a favor del concepto de la ciencia médica de la endocrinología general equivalente.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Spanisch.

Taschenbuch. Zustand: Neu. Neuware -Aunque la técnica de inmunoensayo enzimático que utilizamos es la primera generación, nuestro estudio sigue siendo importante (25, 26, 27). De hecho, nuestro trabajo en 52 pacientes usando 92 pruebas de TRH con levotiroxina y combinación de levotiroxina y triyodotironina nos permitió evaluar el equilibrio hormonal óptimo. Se determinó que la dosis que situaba el delta de la TSH en una zona de eutiroidismo conocido, (4 a 20 micro UI/ml (IRMA)) era de 111,84 + 31,33 microg/d; 72,75 + 7,5 microg/m /d; 1,84 + 0,53 microg/kg/d. Sin embargo, incluso cuando la TSH delta es inferior a 4 micro UI/ml (1,03 + 1,47 micro UI/ml) con la levotiroxina o la combinación de levotiroxina y triyodotironina (1,06 + 1,13 micro UI/ml) sin ninguna diferencia significativa entre las medias de la TSH delta de estos dos grupos, no encontramos ningún cambio en el colesterol o en la frecuencia cardíaca, aparte de una débil correlación negativa (r : 0,105) entre la frecuencia cardíaca y la TSH delta de menos de 4 micro UI/ml cuando se combinaron la levotiroxina y la triyodotironina.Books on Demand GmbH, Überseering 33, 22297 Hamburg 72 pp. Spanisch.

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Taschenbuch. Zustand: Neu. Neuware -El yodo regula el metabolismo nutricional probablemente a través de la microbiota. La tirodiabetes ha sido motivo de preocupación para los médicos. Los disruptores endocrinos nos han recordado que la glándula tiroides es un centinela del medio ambiente que, según nuestro enfoque, da testimonio del papel primordial del yodo mineral en la mayoría de los organismos vivos. Conclusión general : La clasificación de Bastenie es una semiología bioclínica que podría revisarse integrando la obesidad como una etapa incipiente del giro epigenético de la tiroides de la deiodasa realizando una TSH inactiva. El hipotiroidismo primario desde un punto de vista histórico-técnico ha sido reconocido desde Bastenia:1 mixedema por atrofia de la tiroides T4 y T3 disminución y elevación de la TSH.2 hipotiroidismo frugal o sólo elevación de la TSH 3 hipotiroidismo subclínico o sólo la prueba de TRH es positiva .4 tiroiditis o sólo existen autoanticuerpos 5 o está involucrada la vuelta de la desiodasa.Estas son las perspectivas de un practicante en la Clínica Médica y el Pabellón de Enfermedades Endocrinas.Books on Demand GmbH, Überseering 33, 22297 Hamburg 72 pp. Spanisch.