godfraind (33 Ergebnisse)

gebundene Ausgabe. Zustand: Gut. 401 Seiten; Der Erhaltungszustand des hier angebotenen Werks ist trotz seiner Bibliotheksnutzung sehr sauber. Es befindet sich neben dem Rückenschild lediglich ein Bibliotheksstempel im Buch; ordnungsgemäß entwidmet. Einbandkanten sind leicht bestoßen. In ENGLISCHER Sprache. Sprache: Englisch Gewicht in Gramm: 940.

Hardcover. Zustand: Wie neu. 276 S.; Ill. Like new. Shrink wrapped. Sprache: Englisch Gewicht in Gramm: 910.

gebundene Ausgabe. Zustand: Gut. 488 Seiten; Das hier angebotene Buch stammt aus einer teilaufgelösten wissenschaftlichen Bibliothek und trägt die entsprechenden Kennzeichnungen (Rückenschild, Instituts-Stempel.); leichte altersbedingte Anbräunung des Papiers; der Buchzustand ist ansonsten ordentlich und dem Alter entsprechend gut. Einbandkanten sind leicht bestoßen. In ENGLISCHER Sprache. Sprache: Englisch Gewicht in Gramm: 1140.

Hard Cover. Zustand: Acceptable. No Jacket. Ex-library with the usual features. The interior is clean and tight. Binding is good. Cover shows light wear. 322 pages. Ex-Library.

Gebundene Ausgabe. Zustand: Sehr gut. 378 Seiten Exemplar aus einer Unternehmensbibliothek Sprache: Englisch Gewicht in Gramm: 550.

2004. 16 x 24 cm. XIV, 262 S. XIV, 262 p. Hardcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. (Milestones in Drug Therapy). Sprache: Englisch.

Paperback. Zustand: Very Good. 202p large paperback, illustrations, one inserted, clean copy of Thesis, from the library of the late Cambridge Nobel Laureate Sir Andrew Huxley with his name to endpaper Language: French.

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Paperback. Zustand: Brand New. 325 pages. 9.61x6.14x0.76 inches. In Stock.

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Zustand: fine. Envoi soigné, expédition en 24h/48h.

Taschenbuch. Zustand: Neu. Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions | T. Godfraind (u. a.) | Taschenbuch | Developments in Cardiovascular Medicine | 325 S. | Englisch | 2011 | Springer | EAN 9789400960350 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - 2 The free internal Ca+ concentration in human red cells is set according to the leak 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades. As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally. This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.

Hardcover. Zustand: Gut. 322 S., With figures. Good condition. gebraucht; gut Good condition. ha1066517 Sprache: Englisch Gewicht in Gramm: 720.

Hardcover. Zustand: Brand New. 412 pages. 10.00x6.50x1.00 inches. In Stock.

Gebunden. Zustand: New. Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last .

Hardcover. Zustand: Very Good. Only faint wear to cover. Internally, clean and fresh, with unmarked and uncreased pages. Overall, very sound and presentable. Publisher's note: Glass and Glazing looks at the conservation of one of the most important building materials, and its use in windows, roofing and walling. It considers the technological evolution of glass and glazing systems, the processes causing deterioration, and the practical application and long-term implications of common conservation materials and methods, as well as of alterations to improve performance. Size: 24.4 x 22 x 3.3 cm. viii, 487 pp. Shipped Weight: 1-2 kilos. Category: Architecture; Glass construction -- Conservation and restoration; Historic buildings -- Conservation and restoration; ISBN: 0754645576. ISBN/EAN: 9780754645573. Add. Inventory No: 250926NS5207.

Hardcover. Zustand: Very Good. A very presentable copy with minimal wear. Faint wear to cover. All pages clean, crisp and fresh. Publisher's note: Metals deals with the conservation of a group of materials that have been used in buildings for everything from structural components and fixings to weatherproofing, repairs, and decoration. It covers both the iron-based and the non-ferrous metals (such as copper, bronze and lead), in each case considering technological evolution, deterioration processes, and the practical application and long-term implications of the common conservation materials and methods. Size: 24.4 x 22 x 3.1 cm. viii, 461 pp. Shipped Weight: 1-2 kilos. Category: Architecture; Architectural metal-work -- Maintenance and repair; Historic buildings -- Conservation and restoration; ISBN: 075464555X. ISBN/EAN: 9780754645559. Add. Inventory No: 250926NS5406.

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Zustand: New. pp. xiv + 262 Illus.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades.As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally.This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.

Taschenbuch. Zustand: Neu. Pharmacological Control of Calcium and Potassium Homeostasis | Biological, Therapeutical, and Clinical Aspects | T. Godfraind (u. a.) | Taschenbuch | xviii | Englisch | 2012 | Springer | EAN 9789401040563 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The drugs named calcium channel blockers (CCBs) were initially termed cal cium antagonists (see Chapter 1). They are also designated as calcium entry blockers (CEBs), calcium blockers, calcium channel antagonists, calcium channel inhibitors (and in French anticalciques). As this is reported in several chapters of this book, their main effect is a blockade of calcium entry into cells through voltage operated calcium channels (VOCCs). Chemically related drugs, such as Bay K 8644, exert the opposite effect by increasing the proba bility of calcium channel opening. One of the subcommittees of the Nomenclature Committee (NC-IUPAR) of the International Union of Pharmacology has been devoted to the classification of calcium channels and the site of action of drugs modifying channel function. The members of this Committee are noted for their significant contribution to the field (Tab. 1). A report has been published in 1992 in Pharmacological Reviews [3]. A list of criteria was approved for the identification of distinct drug binding 2 sites on Ca + channels. It included: (a) the demonstration of a stereoselective binding site supported by drug interaction studies (competition with other drugs, non-competitive interactions with other sites, reversal of inhibitory effects by channel activators); (b) demonstration of the electrophysiologieal effects of the drug and selectivity of action compared to other sites; (c) deter mination of the affinity for the type and subtype of ion channel. These criteria have identified different classes of Ca antagonists (see Chapter 2).

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives. All chapters are written by Prof. T. Godfraind, a world leading expert in the field.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that bind them have as pharmacological tools and therapeutic agents. This work was presented at the 6th International Symposium on PHARMACOLOGICAL CONTROL OF CALCIUM AND POTASSIUM HOMEOSTASIS: BIOLOGICAL, THERAPEUTICAL, AND CLINICAL ASPECTS, in Florence (Italy) on October 4-6, 1994. Because of the recent advances in the field, discussions on potassium channels were included for the first time. At least six classes of voltage-dependent calcium channels have been defined based on their physiological and pharmacological properties. Among them, L-type channels, mediating long lasting currents, are better characterized. Calcium homeostasis within the cell is not only regulated by calcium channels; intracellular calcium stores, in particular a pool contained in the lumen of specialized areas of the endoplasmic reticulum, are rapidly exchanged with the cytoplasm and playa key role in the control of calcium homeostasis. This area, however, has not yet been exploited from a therapeutic point of view. Potassium channels are present in virtually every cell type, excitable and nonexcitable, and are distinguished by structural, biophysical, and pharmacological criteria. Different classes including voltage-gated, ligand-gated, AP-sensitive, and G-protein coupled among others, have been defined by their primary regulatory and gating mechanisms.