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Verlag: Springer Berlin Heidelberg, 2011
ISBN 10: 3642719864ISBN 13: 9783642719868
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Buch
Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.
Verlag: Lippincott Williams&Wilki, 2022
ISBN 10: 1975142519ISBN 13: 9781975142513
Anbieter: moluna, Greven, Deutschland
Buch
Zustand: New. InhaltsverzeichnisContents  Contributors viiForeword xiiiPreface xvii  Section I. Introduction to Immunology1 Overview of the Immune System &mdash 1M.
Verlag: Lippincott Williams&Wilki Okt 2022, 2022
ISBN 10: 1975142519ISBN 13: 9781975142513
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Buch
Buch. Zustand: Neu. Neuware - Selected as a Doody's Core Title for 2022!Defining the field of immunology for 40 years, Paul's Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It's an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.