crick francis james watson (11 Ergebnisse)

Zustand: Very Good. Prompt Shipment, in Boxes, Tracking First Editions are First Printings. . Very important publication. Symposia has presented many discoveries, such as the structure of DNA, the genetic code, the polymerase chain reaction (PCR), and RNA interference (RNAi)-Featuring the important: Volume XVIII (1953) Watson and Crick DNA (this copy inscribed presentation copy signed by Milislav Demerec who was head of the Laboratory. The recipient was a professor at Cornell.Inluding: XIII (1948), XXVI (1961), XII (1947), X (1942), XI (1946), , XXII (1957), XVII (1952), XXI (1956), XXVIII (1963) Small gouge front cover, IX (1941), XIV (1949), XV (1950) ex-library with few stamps and spine ID letters in white, XL (1975), XXVI (1961), XXVII (1962), XVI (1951), XXIII (1958)Most are in very good condition. Some have the prior owners name, one has a ring stain on cover. A very serviceable group of volumes. Some spine letters darkened, or spine sunned. Biology. Genetics. *Provenance: William B. Provine.

First edition of this riveting work on the legendary scientist James D. Watson. Octavo, original boards. Boldly signed by James Watson and Francis Crick on the half-title page. Fine in a fine dust jacket. Jacket design by Ron Monteleone. Rare and desirable signed by Watson and Crick. In its drama, Watson's life has rivaled the discovery of the structure of DNA. So intent on his research was this awkward, bumbling scholar that he would climb a drainpipe to sneak into a lab at night. Watson had a knack for selecting problems that would yield important scientific results, but did he pilfer? Did Rosalind Franklin originate crucial material? If so, why was she not included in the Nobel Prize? Baldwin, who had exceptional access to Watson and his family, conveys the elegance of science (the ``structure [of DNA] was too pretty not to be true''), describes diverse influences (birding, Arrowsmith, movies), and even gives advice (go to a college where others are brighter than you, to test your mettle). Voluminous detail on what, exactly, provided a lifetime's worth of inspiration broaden an intriguing picture of this intrepid competitor.

Hardcover. Zustand: Very Good. First Edition. First edition. Contains the first publication of a paper by Watson and Crick, which was presented by Watson at the Cold Spring Harbor Symposium, marking the first full account either Watson or Crick delivered on their discovery of the structure of DNA. Publisher's red cloth with gilt lettering to spine. Very Good with two small water splashes to the front cover, light wear to cloth and fading to spine. Small previous owner name to the front free end paper. A scarce title, marking a major milestone in biology.

First edition of Watson's ground breaking work regarding the discovery of DNA for which the author, Francis Crick and Maurice Wilkins were awarded the Nobel Prize in Medicine in 1962. Signed by both James Watson and Francis Crick on the title page. Octavo, original blue cloth, with numerous diagrams and photographic illustrations. Fine in a fine dust jacket. Jacket design by Jeanyee Wong. Foreword by Sir Lawrence Bragg. Rare and desirable signed by both Watson and Crick. "Science seldom proceeds in the straightforward logical manner imagined by outsiders," writes James Watson in The Double Helix, his account of his codiscovery (along with Francis Crick) of the structure of DNA. Watson, Crick and Maurice Wilkins won Nobel Prizes for their work, and their names are memorized by biology students around the world. But as in all of history, the real story behind the deceptively simple outcome was messy, intense, and sometimes truly hilarious. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "One of the investigators, more than any of the others, realized the decisive importance of the DNA molecules in biology, and it was this understanding which urged him relentlessly to push this work toward a successful conclusion, in spite of his rather modest technical qualifications for this task" (Mayr, 823). "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).

First edition of this collection of Nobel Lectures in physiology or medicine from the years 1942-1962. Thick Octavo, original yellow cloth. Signed by all three Nobel Prize-winning scientists Francis Crick, James D. Watson and Maurice Wilkins on the title page. They were awarded the Nobel Prize in Medicine in 1962, "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material."Fine in a very good dust jacket with some closed tears and toning to the spine. An exceptional piece signed by these Nobel Prize-winning scientists. In the early 1950s, the race to discover DNA was on. At Cambridge University, graduate student Francis Crick and research fellow James Watson had become interested, impressed especially by Pauling's work. Meanwhile at King's College in London, Maurice Wilkins (b. 1916) and Rosalind Franklin were also studying DNA. The Cambridge team's approach was to make physical models to narrow down the possibilities and eventually create an accurate picture of the molecule. The King's team took an experimental approach, looking particularly at x-ray diffraction images of DNA. Watson and Crick took a crucial conceptual step, suggesting the molecule was made of two chains of nucleotides, each in a helix as Franklin had found, but one going up and the other going down. Crick had just learned of Chargaff's findings about base pairs in the summer of 1952. He added that to the model, so that matching base pairs interlocked in the middle of the double helix to keep the distance between the chains constant. Watson and Crick showed that each strand of the DNA molecule was a template for the other. During cell division the two strands separate and on each strand a new "other half" is built, just like the one before. This way DNA can reproduce itself without changing its structure -- except for occasional errors, or mutations. The structure so perfectly fit the experimental data that it was almost immediately accepted. DNA's discovery has been called the most important biological work of the last 100 years, and the field it opened may be the scientific frontier for the next 100.

First edition of the collected speeches of the 52nd Cold Spring Harbor Symposia on Quantitative Biology. Foreword by James D. Watson. Quarto, original red cloth, illustrated with photographs, diagrams. Association copy, inscribed by James Watson to Francis Crick on the front free endpaper, "For Francis, the first of us to think sensibly as to what the Central Dogma tells us about the origin of life, from Jim, upon the 35th anniversary of the Double Helix. April 10, 1988." Also signed by Francis Crick. A unique piece of history between arguably the two most influential scientists of the twentieth century, co-discoverers of the structure of DNA. In near fine condition. Housed in a custom slipcase. An exceptional association linking the discoverers of the molecular structure of DNA. Participants of the 52nd Symposia on Quantitative Biology included James D. Watson, James Darnell, Peter Moore, Raul Saavedra, and Fusao Tomita, each of whom spoke on a wide range of topics related to the discovery, structure and informational properties of RNA. Watson made his first trip to Cold Spring Harbor in 1948 at the age of 20, he returned 5 years later to make his seminal presentation reporting the discovery of DNA, for which he and Francis Crick would be awarded the Nobel Prize. Watson's "second act" commenced in 1968, when, following the publication of The Double Helix, he became the laboratory's Director. During his tenure, he transformed CSHL from an institution suffering from a lack of funding into one of the world's primary biomedical research centers.

First edition of Watson's ground breaking work regarding the discovery of DNA for which the author, Francis Crick and Maurice Wilkins were awarded the Nobel Prize in Medicine in 1962.ÂOctavo, original cloth, illustrated with 19 half-tone illustrations and 11 diagrams. Signed by both James D. Watson and Francis Crick on the title page. Very good in an excellent dust jacket with some light rubbing to the spine crown. Jacket design by Dorothy Judd. Foreword by Sir Lawrence Bragg. Rare signed by both Watson and Crick. "Science seldom proceeds in the straightforward logical manner imagined by outsiders," writes James Watson in The Double Helix, his account of his codiscovery (along with Francis Crick) of the structure of DNA. Watson, Crick and Maurice Wilkins won Nobel Prizes for their work, and their names are memorized by biology students around the world. But as in all of history, the real story behind the deceptively simple outcome was messy, intense, and sometimes truly hilarious. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "One of the investigators, more than any of the others, realized the decisive importance of the DNA molecules in biology, and it was this understanding which urged him relentlessly to push this work toward a successful conclusion, in spite of his rather modest technical qualifications for this task" (Mayr, 823). "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).

First edition, the three-paper offprint issue, of the primary record of the co-discovery of the molecular structure of DNA. This copy is from the library of Professor Hans Gustav Boman (1924-2008), the leading molecular biologist in Sweden; his signature is in ink on the first page. Three research groups independently investigated the structure of DNA in England in the early 1950s: Francis Crick and James Watson at the Cavendish Laboratory in Cambridge and two teams at King's College, London comprising Maurice Wilkins, Rosalind Franklin, Raymond Gosling, Alec Stokes, and Herbert Wilson. To acknowledge the simultaneity of the discovery, the directors of the respective institutions agreed that the three resulting papers would be published under the general title Molecular Structure of Nucleic Acids in the British scientific weekly Nature. Crick and Watson's paper, "A Structure for Deoxyribose Nucleic Acid", is illustrated with a schematic drawing by Odile Crick of the twisted-ladder structure of DNA, now famously known as the double helix. Wilkins, Stokes, and Wilson co-wrote "Molecular Structure of Deoxypentose Nucleic Acids", the second paper. Franklin and her research student Gosling submitted "Molecular Configuration in Sodium Thymonucleate", which features a half-tone illustration of Gosling's iconic X-ray "Photograph 51" of crystallized DNA. Franklin died four years before the Nobel Prize in Physiology or Medicine was awarded to Crick, Watson, and Wilkins in 1962 for their work on DNA, but without question her "contributions, and indeed her actual X-ray data, were crucial to the total achievement" (ODNB). "Two offprints exist of Watson and Crick's paper: a single sheet containing the Watson and Crick article only, and a fourteen-page pamphlet containing the papers of all three research groups. The pamphlet pages are smaller in size than the single leaf, which has the same dimensions as the leaves of the journal, and the layout is different, the single-leaf offprint being printed in two columns like the journal, the pamphlet in single-column pages. The page breaks are different in each of the two offprints and the journal, as is the placement of the illustrations relative to the text. Despite these differences, all three versions appear to have been printed from the same setting of type, except that in the two offprints one paragraph of text has been reset to accommodate the placement of the diagram of the DNA molecule" (Grolier, p. 363). Haskell F. Norman discusses the difficulty in establishing priority between the two formats in his introduction to One Hundred Books Famous in Medicine and closes by stating that "it is now our tentative conclusion that the three-paper offprint is the first issue" (p. xxi). Boman "was one of the pioneers in the field of molecular biology in Sweden" (Norrby, p. 11). After teaching at Uppsala University he transferred to Umeå University to establish their microbiology department; under his leadership it became an international hub of research excellence. "Halfway through his career Boman moved on to Stockholm University and initiated a completely new line of research. It pioneered the development of insights into the emerging field of natural immunity. He developed this work in collaboration with Swedish colleagues and coined the term cecropines for this new kind of peptide antibiotics. This was a Nobel-class discovery" but - like Franklin - Boman died before he could see his research recognized as such (Norrby, p. 11). In 2011, his work formed the basis of a discovery by Jules Hoffman and Bruce Beutler, for which they received the Nobel Prize in Physiology or Medicine. Garrison-Morton 256.3 (Crick and Watson's paper); Grolier, One Hundred Books Famous in Medicine, 99; Heirs of Hippocrates 2342. Erling Norrby, Nobel Prizes: Cancer, Vision and the Genetic Code, 2019. Octavo, pp. 14. With 4 illustrations. Printed pamphlet, wire-stitched as issued. A few neat red pencil marks to first three pages, lower outer corners creased: a near-fine copy.

Watson, James D. (1928- ); Francis H. C. Crick (1916-2004). Collection of offprints (including 4 signed by Crick), four typed letter signed by Watson, and other related items, as listed below. 1954 2005. Overall very good; see below for individual condition statements. First Editions, Offprint Issues of the papers except as noted. watson and Crick's discovery of the double-helical structure of DNA is generally regarded as the most important biological and medical discovery of the second half of the 20th century. We are offering here a selection of their later papers on topics in molecular biology, along with a series of letters from Watson to Australian physician Kevin J. Fraser. Crick. The structure of the hereditary material. Offprint from Scientific American (October 1954). 7, [1]pp. 278 x 212 mm. Without wrappers as issued. Signed by Crick on the first leaf. A few marginal pencil annotations. Crick. The structure of the hereditary material. In Scientific American (October 1954): 54-61. Whole number. 295 x 220 mm. Original printed wrappers, some wear and soiling. Signed by Crick on the first page of the article. Crick. The genetic code. Offprint from Scientific American (October 1962). 9, [1]pp. 278 x 212 mm. Without wrappers as issued. Signed by Crick on the first leaf. Ownership stamp. Crick. The genetic code: III. Offprint from Scientific American (October 1966). 9, [3]pp. 278 x 212 mm. Without wrappers as issued. Signed by Crick on the first leaf. Ownership stamp. Crick and Aaron Klug (1926-2018). Kinky helix. Offprint from Nature 255 (1975). [4]pp. 280 x 214 mm. Without wrappers as issued. Watson. Genetic evidence in Escherichia coli K12: Evidence for three linkage groups. Offprint from Proceedings of the National Academy of Sciences 39 (1953). 416-426pp. 258 x 175 mm. Original printed wrappers. Stamp of molecular biologist Rollin D. Hotchkiss (1911-2004) on the front wrapper. Watson. The structure of tobacco mosaic virus. I. X-ray evidence of a helical arrangement of sub-units around the longitudinal axis. Offprint from Biochemica and Biophysica Acta 13 (1954). 10-19pp. Original printed self-wrappers. Light creasing, small tear in front wrapper. Watson and A. Tissières. Ribonucleoprotein particles from Escherichia coli. Offprint from Nature 182 (1958). 6, [1]pp. 212 x 141 mm. Original printed wrappers. Stamp of molecular biologist Gunther Stent (1924-2008) on the front wrapper. Watson et al. Molecular and biological characterization of messenger RNA. Offprint from Cold Spring Harbor Symposia on Quantitative Biology 26 (1961). 111-132pp. 273 x 199 mm. Original printed wrappers, horizontally creased. Stamp of molecular biologist Rollin D. Hotchkiss (1911-2004) on the front wrapper. Watson. DNA 50 years ago and today. Computer-generated typescript. 13ff. N.p., 28 April 2003. 298 x 213 mm. Text of Watson's address delivered at "A Celebration of the DNA Double Helix at 50," held at Trinity College, Dublin. Watson. Four typed letters signed to Australian physician and collector Kevin J. Fraser, together with Fraser's file copies of four typed letters to Watson. 14 April 1983 31 January 2005. Topics discussed include the offprint of Watson and Crick's 1953 paper; the 1962 Nobel Prize shared by Watson, Crick and Wilkins; Watson's The Double Helix (1968) and its sequel, Genes, Girls and Gamov (2001). .

Nature 1953. 8vo. 2 vols. Contemporary red morocco backed buckram, gilt lettering to spine; vols 171 and 172 of the journal Nature, covering 1953; diagrams and illustrations; very good. First editions of the first papers on the ground-breaking discovery of the structure of DNA, comprising: "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid", in Nature Vol.171, No. 4356, pp.737-738, 25th April, 1953 [and] Wilkins, Maurice H.F., A.R. Stokes and H.R. Wilson. "Molecular Structure of Deoxypentose Nucleic Acids", in Nature Vol.171, No. 4356, pp.738-740, 25th April, 1953 [and] Franklin (Rosalind E.) and R.G. Gosling. "Molecular Configuration in Sodium Thymonucleate", in Nature Vol.171, No. 4356, pp.740-741, 25th April, 1953 [and] Watson (James D.) & Francis Crick. "Genetic Implications of the Structure of Deoxyribonucleic Acid", in Nature Vol.171, No. 4361, pp.964-967, 30th May, 1953 [and] Wilkins (M. H. F.), W. E. Seeds, A. R. Stokes and H. R. Wilson. "Helical Structure of Crystalline Deoxypentose Nucleic Acid", in Nature, vol.172, No. 4382, pp.759-762, 24th October, 1953. These papers record the greatest biological advance of the twentieth century, a discovery which won Crick, Watson and Wilkins the Nobel Prize.

Original photograph from the 1962 Nobel Prize Ceremony signed by Francis Crick, James Watson, and Maurice Wilkins (jointly awarded the 1962 Nobel Prize in Physiology and Medicine) as well as Max Ferdinand Perutz and John Kendrew (jointly awarded the 1962 Nobel Prize in Chemistry). Also captured in the photograph is John Steinbeck, who was awarded the 1962 Nobel Prize in Literature. In fine condition. The Nobel Prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and Maurice Hugh Frederick Wilkins "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material." In 1968, Watson published The Double Helix: A Personal Account of the Discovery of the Structure of DNA, his account of his codiscovery (along with Francis Crick) of the structure of DNA. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).