Amaratunga dhammika (8 Ergebnisse)
- Softcover
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Zustand: New. In.
Sprache: Englisch
Verlag: Wiley-Interscience, 2003
Serie: Buch 188 von 358 - Wiley Series in Probability and Statistics
- Hardcover
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Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
- Softcover
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Paperback. Zustand: Brand New. 2012 edition. 297 pages. 9.00x6.00x0.50 inches. In Stock.
Sprache: Englisch
Verlag: John Wiley & Sons, 2003
Serie: Buch 188 von 358 - Wiley Series in Probability and Statistics
- Hardcover
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Zustand: New. pp. xiv + 246 Illus.
Weitere Bilder- Softcover
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Taschenbuch. Zustand: Neu. Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R | Order-Restricted Analysis of Microarray Data | Dan Lin (u. a.) | Taschenbuch | Use R! | xv | Englisch | 2012 | Springer | EAN 9783642240065 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17…, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
- Softcover
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EUR 59,97
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze thi…s data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:- Multiplicity adjustment- Test statistics and procedures for the analysis of dose-response microarray data- Resampling-based inference and use of the SAM method for small-variance genes in the data- Identification and classification of dose-response curve shapes- Clustering of order-restricted (but not necessarily monotone) dose-response profiles- Gene set analysis to facilitate the interpretation of microarray results- Hierarchical Bayesian models and Bayesian variable selection- Non-linear models for dose-response microarray data- Multiple contrast tests- Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rateAll methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.
- Softcover
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Zustand: Gut. Zustand: Gut | Seiten: 300 | Sprache: Englisch | Produktart: Bücher | This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze… this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:¿ Multiplicity adjustment¿ Test statistics and procedures for the analysis of dose-response microarray data¿ Resampling-based inference and use of the SAM method for small-variance genes in the data¿ Identification and classification of dose-response curve shapes¿ Clustering of order-restricted (but not necessarily monotone) dose-response profiles¿ Gene set analysis to facilitate the interpretation of microarray results¿ Hierarchical Bayesian models and Bayesian variable selection¿ Non-linear models for dose-response microarray data¿ Multiple contrast tests¿ Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rateAll methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.
Sprache: Englisch
Verlag: John Wiley & Sons Inc, 2014
Serie: Buch 256 von 358 - Wiley Series in Probability and Statistics
- Hardcover
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EUR 185,87
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Zustand: New. This new edition answers the need for a comprehensive, cutting-edge overview of this important and emerging field effectively outlining all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Series: Wiley Series in Probability and Statistics. Num Pages: 344 pages, illustrat…ions. BIC Classification: PBT; PSAK1. Category: (P) Professional & Vocational. Dimension: 242 x 157 x 23. Weight in Grams: 592. . 2014. 2nd Edition. Hardcover. . . . . Books ship from the US and Ireland.
