Vol 515, No. 7526, November 2014, The Great Depression

Sprache: Deutsch

Verlag: NPG Nature publishing group

Anbieter: Antiquariat Artemis Lorenz & Lorenz GbR, Leipzig, DeutschlandAntiquariat Artemis Lorenz & Lorenz GbR

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Mental health: Depression needs large human-genetics studies To understand the molecular mechanisms of depression, collect genetic data from more than 100,000 people, says Steven Hyman. Infectious disease: Tough choices to reduce Ebola transmission Christopher J. M. Whitty and colleagues explain why the United Kingdom is funding many small community centres to isolate suspected cases in Sierra Leone. Film: Enigma variations Robert P. Crease ponders a brace of biopics on Alan Turing and Stephen Hawking. Review of The Imitation Game and The Theory of Everything Morten Tyldum & James Marsh Q&A: Space-time visionary Thanks to theoretical physicist Kip Thorne, real science is embedded in Christopher Nolan's film Interstellar, in which explorers seek a new home for humankind. Thorne talks about what he learned from the film's unprecedented visualizations of black holes and wormholes, what it and his accompanying book can teach, and the likelihood of humans escaping the Solar System. Review of Interstellar and The Science of Interstellar Christopher Nolan & Kip Thorne Books in brief Barbara Kiser reviews five of the week's best science picks. Sickle-cell disease Lauren Gravitz & Stephen Pincock Epidemiology: A moving target Simon Pleasants Drug development: A complicated path Courtney Humphries Q&A: Healthy progress Smriti Mallapaty Neurobiology: Life beyond the pain Bianca Nogrady Perspective: We need a global solution Isaac Odame Gene therapy: Editorial control Katharine Gammon Stem cells: Creating a cure-all Andrew R. Scott Perspective: Thinking beyond survival Michael R. DeBaun Forum Depression: The best way forward Lisa M. Monteggia, Robert C. Malenka & Karl Deisseroth Condensed-matter physics: Magnetic fields without magnetic fields Jonathan Simon See also Letter by Jotzu et al. See also Letter by Roushan et al. Palaeontology: Mystery of the horrible hands solved Thomas R. Holtz Jr See also Letter by Lee et al. High-temperature superconductivity: Electron mirages in an iron salt Jan Zaanen See also Letter by Lee et al. Neurobiology: Building a bigger brain Forrest O. Gulden & Nenad ?estan See also Letter by Lui et al. Neuroscience: Towards unified vesicle endocytosis Vladan Lu?i? See also Article by Watanabe et al. Articles Top Synaptic, transcriptional and chromatin genes disrupted in autism Silvia De Rubeis, Xin He, Arthur P. Goldberg, Christopher S. Poultney, Kaitlin Samocha + et al. Whole-exome sequencing in a large autism study identifies over 100 autosomal genes that are likely to affect risk for the disorder; these genes, which show unusual evolutionary constraint against mutations, carry de novo loss-of-function mutations in over 5% of autistic subjects and many function in synaptic, transcriptional and chromatin-remodelling pathways. The contribution of de novo coding mutations to autism spectrum disorder Ivan Iossifov, Brian J. O?Roak, Stephan J. Sanders, Michael Ronemus, Niklas Krumm + et al. Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to the incidence of simplex autism, with target genes in affected females overlapping those in males of lower but not higher IQ; targets also overlap known targets for intellectual disability and schizophrenia, and are enriched for chromatin modifiers, FMRP-associated genes and embryonically expressed genes. Evolution of mosquito preference for humans linked to an odorant receptor Carolyn S. McBride, Felix Baier, Aman B. Omondi, Sarabeth A. Spitzer, Joel Lutomiah + et al. The mosquito Aedes aegypti includes two subspecies, one of which shows a preference for biting humans, whereas the other prefers to bite non-human animals; genetic analysis reveals that changes in the mosquito odorant receptor Or4 contribute to the behavioural difference?in human-preferring mosquitoes, Or4 is more highly expressed and more sensitive to sulcatone, a c.

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Bibliografische Details

Titel
Vol 515, No. 7526, November 2014, The Great Depression
Autor
nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE
Verlag
NPG Nature publishing group
Sprache
Deutsch
Artikelgewicht
400 Gramm

Antiquariat Artemis Lorenz & Lorenz GbR

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AbeBooks-Verkäufer/-in seit 26. März 2015

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