Beschreibung
Society: Don, t blame the mothers Careless discussion of epigenetic research on how early life affects health across generations could harm women, warn Sarah S. Richardson and colleagues. Books and Arts Top History of engineering: Wonder maker Andrew Robinson delves into a study inspired by James Watt, s fascinating workshop. Review of James Watt: Making the World Anew Ben Russell Books in brief Barbara Kiser reviews five of the week s best science picks. Neuroscience: What females really want Leslie C. Griffith Solar system: Sandcastles in space Daniel J. Scheeres See also Letter by Rozitis et al. Ageing: Old blood stem cells feel the stress Jiri Bartek & Zdenek Hodny See also Letter by Flach et al. Condensed-matter physics: Glasses made from pure metals Jan Schroers See also Letter by Zhong et al. Cancer: One cell at a time Edward J. Fox & Lawrence A. Loeb See also Article by Wang et al. Astronomical instrumentation: Atmospheric blurring has a new enemy Brent Ellerbroek Structural biology: Corralling a protein-degradation regulator Raymond J. Deshaies See also Article by Lingaraju et al. Limits on fundamental limits to computation Igor L. Markov To evaluate the promise of potential computing technologies, this review examines a wide range of fundamental limits, such as to performance, power consumption, size and cost, from the device level to the system level. Articles Top Clonal evolution in breast cancer revealed by single nucleus genome sequencing Yong Wang, Jill Waters, Marco L. Leung, Anna Unruh, Whijae Roh + et al. To investigate genomic diversity within tumours, a new type of whole-genome and exome single cell sequencing has been developed using G2/M nuclei, the technique was used to sequence single nuclei from an oestrogen-positive breast cancer and a triple-negative ductal carcinoma aneuploidy rearrangements emerged as early events in tumour formation and then point mutations evolved gradually over time. See also News & Views by Fox & Loeb Crystal structure of the human COP9 signalosome Gondichatnahalli M. Lingaraju, Richard D. Bunker, Simone Cavadini, Daniel Hess, Ulrich Hassiepen + et al. The COP9 signalosome (CSN) complex regulates cullin RING E3 ubiquitin ligases the largest class of ubiquitin ligase enzymes, which are involved in a multitude of regulatory processes, here, the crystal structure of the entire human CSN holoenzyme is presented. See also News & Views by Deshaies Three-dimensional structure of human -secretase Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan + et al. The three-dimensional structure of intact human -secretase complex at 4.5 Å resolution is revealed by cryo-electron-microscopy single-particle analysis, the complex comprises a horseshoe-shaped transmembrane domain containing 19 transmembrane segments, and a large extracellular domain from nicastrin, which sits immediately above the hollow space formed by the horseshoe. Letters Top The origin of the local 1/4-keV X-ray flux in both charge exchange and a hot bubble M. Galeazzi, M. Chiao, M. R. Collier, T. Cravens, D. Koutroumpa + et al. The contribution of solar-wind ions exchanging electrons with helium and hydrogen near the Sun is shown to be only about 40 per cent of the 1/4-keV X-ray flux observed in the Galactic plane, this supports the existence of a local hot bubble filled with X-ray-emitting gas, accounting for the rest of the flux. Cohesive forces prevent the rotational breakup of rubble-pile asteroid (29075) 1950 DA Ben Rozitis, Eric MacLennan & Joshua P. Emery Modelling and observations of the kilometre-sized asteroid (29075) 1950 DA reveal it to be a rubble pile that is rotating faster than is allowed by gravity and friction, cohesive forces such as those in lunar regolith are required to prevent it breaking up. See also News & Views by Scheeres Formation of monatomic metallic glasses through ultrafast liquid quenching Li Zhong, Jiangwei Wang, Hongwei Sheng, Ze Zhang & Scott X. Mao Metallic liquids of single elements.
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