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Policy: An intergovernmental panel on antimicrobial resistance Drug-resistant microbes are spreading. A coordinated, global effort is needed to keep drugs working and develop alternatives, say Mark Woolhouse and Jeremy Farrar. Health care: Bring microbial sequencing to hospitals Analysing bacterial and viral DNA can help doctors to pick effective drugs quickly, says Sharon Peacock. Cosmology: Matter and mixology Francis Halzen is exhilarated by an account of the hunt for the particles of dark matter. Review of The Cosmic Cocktail: Three Parts Dark Matter Katherine Freese Books in brief Q&A: The space crusader US astronomer Neil deGrasse Tyson, director of New York, s Hayden Planetarium, currently hosts the television series Cosmos an update of Carl Sagan, s 1980 show broadcast in 181 countries and 45 languages. As it winds down, Tyson talks about the rich mix of science and pop culture, the , neurosynaptic snapshot, of public responses to his tweets, and his momentous meeting with Sagan. Cancer Herb Brody Statistics: Attacking an epidemic Mike May Therapy: This time it, s personal Lauren Gravitz Clinical trials: More trials, fewer tribulations Michael Eisenstein Nanotechnology: Deliver on a promise Jessica Wright Comparative biology: Naked ambition Sarah Deweerdt Prevention: Air of danger Rebecca Kessler Developing world: Global warning Eric Bender Bioinformatics: Big data versus the big C Neil Savage Perspective: Learning to share John Quackenbush Biology: Three known unknowns Katherine Bourzac Climate science: A sink down under Daniel B. Metcalfe See also Letter by Poulter et al. Microbiology: Barriers to the spread of resistance Morten O. A. Sommer See also Letter by Forsberg et al. Materials science: Energy storage wrapped up Yury Gogotsi 50 & 100 Years Ago Developmental genetics: Female silkworms have the sex factor Franti ek Marec See also Letter by Kiuchi et al. Precision measurement: The magnetic proton V. Alan Kostelecký See also Letter by Mooser et al. Cardiovascular biology: Switched at birth Katherine E. Yutzey Immunology: To affinity and beyond David M. Tarlinton See also Letter by Gitlin et al. Articles Top A draft map of the human proteome Min-Sik Kim, Sneha M. Pinto, Derese Getnet, Raja Sekhar Nirujogi, Srikanth S. Manda + et al. A draft map of the human proteome is presented here, accounting for over 80% of the annotated protein-coding genes in humans, some novel protein-coding regions, including translated pseudogenes, non-coding RNAs and upstream open reading frames, are identified. Mass-spectrometry-based draft of the human proteome Mathias Wilhelm, Judith Schlegl, Hannes Hahne, Amin Moghaddas Gholami, Marcus Lieberenz + et al. A mass-spectrometry-based draft of the human proteome and a public database for analysis of proteome data are presented, assembled information is used to estimate the size of the protein-coding genome, to identify organ-specific proteins, proteins predicting drug resistance or sensitivity, and many translated long intergenic non-coding RNAs, and to reveal conserved control of protein abundance. Structural basis of the non-coding RNA RsmZ acting as a protein sponge Olivier Duss, Erich Michel, Maxim Yulikov, Mario Schubert, Gunnar Jeschke + et al. A novel combined NMR and EPR spectroscopy approach reveals the structure and assembly mechanism of a 70-kDa bacterial ribonucleoprotein complex acting as a protein sponge in translational regulation. Letters Top Three regimes of extrasolar planet radius inferred from host star metallicities Lars A. Buchhave, Martin Bizzarro, David W. Latham, Dimitar Sasselov, William D. Cochran + et al. Analysis of the metallicities of more than 400 stars hosting 600 candidate extrasolar planets shows that the planets can be categorized by size into three populations terrestrial-like planets, gas dwarf planets with rocky cores and hydrogen helium envelopes, and ice or gas giant planets on the basis of host star metallicity. Direct high-precision measurement o. Bestandsnummer des Verkäufers B00042577
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