If you live with relentless exhaustion, post-exertional malaise (PEM), brain fog or “normal” test results that explain nothing, this book will finally help you understand what’s really going on.
Millions with ME/CFS, Long Covid, and post-viral fatigue are told their symptoms are a mystery. But emerging research may at last reveal the underlying mechanisms — and offer a path toward meaningful improvement.
In this clear, direct, and deeply hopeful guide, ME/CFS patient Patrick Ussher explains the breakthrough model proposed by Professors Klaus Wirth and Carmen Scheibenbogen. Their work brings together the major abnormalities seen in ME/CFS — low blood volume, microclots, autonomic dysfunction, mitochondrial impairment, autoimmunity, and more — into one interconnected cycle.
It may finally explain why activity triggers PEM, why rest doesn’t restore energy, and why so many develop chronic fatigue after a viral illness.
This book goes far beyond theory. It offers practical tools, science-based insights, and real-world strategies that patients use to manage symptoms and improve quality of life.
Inside, you’ll learn about:Breathing techniques to improve oxygenation
Ancestral nutrition and gut repair
Microclot-oriented treatment approaches
Blood-washing procedures (HELP Apheresis & Immunoadsorption)
The Perrin Technique (for spinal & lymphatic health)
The strengths and limits of neuroplasticity (“brain retraining”)
Pacing, PEM management, and mitochondrial support
The potential “Mitodicure” pill which could become the world's first ME/CFS-specific medication
Patrick also shares his own ME/CFS journey with honesty and clarity: what has helped him, what has not, and how he learned to navigate a misunderstood illness with both realism and hope.
If you live with:
…this book will give you a clear framework for understanding your symptoms and practical strategies that might help you feel better.
Straightforward. Evidence-based. Patient-centred.
A guide for anyone seeking answers about the most mysterious of illnesses.
Includes a foreword by Prof. Klaus Wirth who is developing the Mitodicure medication.
Important information: regarding audiobook version (narrated with Amazon's Virtual Voice)
This can be found if you search for the book on audible.com. Readers all around the world can find and listen to the book there (though it is not available directly on audible.co.uk, .fr, etc...)
Patrick Ussher is a writer, editor, and thinker with a particular focus on Stoicism and the practical role of philosophy in modern life. He is the editor of Stoicism Today: Selected Writings (Volumes I & II) and the author of Stoicism and Western Buddhism: A Reflection on Two Philosophical Ways of Life. His work explores how ancient thought can inform contemporary challenges, from emotional resilience to the cultivation of clarity and character.He holds a BA and MA in Classics from the University of Exeter, where he studied ancient philosophy, and has spent many years engaged in the modern Stoic movement through writing, editorial work, and public discussion. His approach emphasises the lived experience of philosophy - not only what we think, but how we live.
