viii 352p large format paperback, from a Cambridge college library, fitted with adhesive film to cover, a bright, fresh and clean copy, never used. Buchnummer des Verkäufers
Inhaltsangabe: This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer.
The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.
About the Author: William B. Pratt, Raymond W. Ruddon, William D. Ensminger, and Jonathan Maybaum are all at University of Michigan Medical School.
Titel: The Anticancer Drugs.
Verlag: Oxford University Press
Zustand: Very Good
Buchbeschreibung Springer, 1992. Gebundene Ausgabe. Buchzustand: Gut. 296 Seiten Gepflegtes ehemaliges Bibliotheksexemplar mit den üblichen Kennzeichnungen (z.B. Barcode und Inventarisierungsnummer); in der Regel foliiert (Umschlag aus selbstklebender Folie). Zustand unter Berücksichtigung des Alters gut. Tagesaktueller, sicherer und weltweiter Versand. Wir liefern grundsätzlich mit beiliegender Rechnung. 326578.01 Sprache: Englisch Gewicht in Gramm: 608. Artikel-Nr. 68092
Buchbeschreibung Editions Universitaires Europeennes EUE Jun 2017, 2017. Taschenbuch. Buchzustand: Neu. Neuware - In the past 50 years, doxorubicin (DOX) known as adriamycin remains one of the most effective chemotherapeutic anticancer drugs for the treatment of different types of cancers. We compare the binding sites of doxorubicin with DNA and tRNA. DOX binding is via intercalation into DNA duplex, while it binds to tRNA through major and minor grooves. DOX-DNA intercalation is close to A-7, C-5, C-19 (H-bonding with DOX NH2 group), G-6, T-8 and T-18 with the free binding energy of -4.99 kcal/mol. DOX-tRNA bindings are near A-29, A-31, A-38, C-25, C-27, C-28, G-30 (H-bonding) and U-41 with the free binding energy of -4.44 kcal/mol. Drug intercalation induced a partial B to A-DNA transition, while tRNA remained in A-family structure. The structural differences observed between DOX bindings to DNA and tRNA can be the main reasons for drug antitumor activity. The results of in vitro MTT assay on SKC01 colon carcinoma are consistent with the observed DNA structural changes. 96 pp. Englisch. Artikel-Nr. 9783330877061
Buchbeschreibung Noor Publishing Mai 2017, 2017. Taschenbuch. Buchzustand: Neu. Neuware - Drug delivery is one of the most challenging fields today due to the development of drugs which have low aqueous solubility, and bioavailability. Instead of wasting millions of dollars and years on screening for new drugs, why not invest in increasing the efficacy of existing ones Biosurfactants are amphiphillic molecules that display exotic surface active properties. They are promising biodegradable and biocompatible molecules that could be produced by a wide range of organisms. They can form structures called micelles that could encapsulate insoluble molecules and increase their bioavailability and solubility; such as drugs. In this project, the biosurfactant sophorolipid was used to enhance the solubility and delivery of an anticancer drug, camptothecin. The data obtained showed the significant effect of sophorolipids in which they maximized the solubilisation capacity of pluronic micelles. All in all, scientists are continuously searching for biocompatible molecules that could solve the never ending problems of drug delivery, sophorolipids should be considered in future pharmaceutical applications because they meet the search criteria perfectly. 108 pp. Englisch. Artikel-Nr. 9783330965270