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Relevance of Animal Studies to the Evaluation of Human Cancer Risk (Progress in clinical and Biological research, Volume 374)

D'Amato, Robert (ed.); slaga, Thomas J. (ed.); farland, William H. (ed.); henry, Carol (ed.)

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ISBN 10: 0471561835 / ISBN 13: 9780471561835
Verlag: Wiley-Liss, New York, 1992
Gebraucht Zustand: Very Good Hardcover
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Bibliografische Details

Titel: Relevance of Animal Studies to the ...

Verlag: Wiley-Liss, New York

Erscheinungsdatum: 1992

Einband: hardcover

Zustand:Very Good

Zustand des Schutzumschlags: No Dust Jacket

Auflage: First Edition.

Art des Buches: Used

Über diesen Titel

Inhaltsangabe:

Progress in Clinical and Biological Research, Volume 374 Relevance of Animal Studies to the Evaluation of Human Cancer Risk Proceedings of a Symposium held December 5–8, 1990 in Austin, Texas Robert D’Amato, Thomas J. Slaga, William H. Farland, and Carol Henry, Editors The carcinogen bioassay in rodents has been a preferred method of screening chemicals for carcinogenicity for several decades. The reliability of this methodology has recently come under scrutiny, however, raising scientific and social value issues and necessitating a re-evaluation of this approach toward assessing human risk. Relevance of Animal Studies to the Evaluation of Human Cancer Risk offers an authoritative review of research trends and current issues in carcinogenesis and risk management. The book focuses on five categories of case studies comparing human and animal data as a means of understanding the factors that are crucial to the action of carcinogens in humans: physical carcinogens with both strong experimental animal and human data; chemical carcinogens with both strong experimental animal and human data; chemotherapeutic agents and secondary tumors; drugs and environmental tumors; and carcinogenic enhancing agents and/or tumor promoters. Highlighting major scientific and research issues as they relate to these case studies, Relevance of Animal Studies to the Evaluation of Human Cancer Risk features in-depth discussion and review of such topics as:

  • carcinogenic effects of certain chemotherapeutic agents, alkylating agents, and their relation to carcinogenesis
  • interspecies sensitivity to important chemical carcinogens and their possible mechanism of action in each species
  • animal inhalation studies to assess the risk of pulmonary cancer induced by mineral fiber
  • benzene dosimetry in experimental animals and molecular dosimetry of aflatoxin DNA adducts in humans and rats
  • cancer enhancement by cell proliferation
Spectacular increases in the amount of information available on cancer biology and pathogenesis make Relevance of Animal Studies to the Evaluation of Human Cancer Risk an especially timely and useful compilation and an essential reference for cancer and radiation biologists, toxicologists, pharmacologists, biochemists, and molecular and cellular biologists, as well as any scientist involved in the study of environmental health hazards.

From the Publisher:

Presents contemporary issues and research in carcinogenesis and risk assessment with emphasis on cellular, biochemical and molecular data which greatly aids in comparing and evaluating cancer risk from chemical and radiation exposure in humans and animals. The relation of chemotherapeutic agents to secondary tumors, drugs and environmental hazards plus carcinogenic-enhancing agents are also discussed. Animal-human comparison has become an indispensable tool to both governmental and industrial regulatory agencies.

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