New Vaccine Development: Establishing Priorities: Diseases Of Importance In Developing Countries

Common diseases cost the developing world an enormous amount in terms of human life, health, and productivity, as well as lost economic potential. New and effective vaccines could not only improve the quality of life for millions of residents in developing countries, they could also contribute substantially to further economic development. Using data from the World Health Organization and other international agencies, this book analyzes disease burdens, pathogen descriptions, geographic distribution of diseases, probable vaccine target populations, alternative control measures and treatments, and future prospects for vaccine development. New Vaccine Development provides valuable insight into immunological and international health policy priorities.

• Front Matter
• 1. Summary
• 2. Priority Setting for Health-Related Investments: A Review of Methods
• 3. Overview of the Analytic Approach
• 4. Comparison of Disease Burdens
• 5. Predictions of Vaccine Development
• 6. Assessing the Likely Utilization of New Vaccines
• 7. Calculation and Comparison of the Health Benefits and Differential Costs Associated with Candidate Vaccines
• 8. Additional Issues in the Selection of Priorities for Accelerated Vaccine Development
• 9. Findings, Conclusions, and Recommendations
• Appendix A: Selection of Vaccine Candidates for Accelerated Development
• Appendix B: The Burden of Disease Resulting from Acute Respiratory Illness
• Appendix C: The Burden of Disease Resulting from Diarrhea
• Appendix D-1: The Prospects for Immunizing Against Dengue Virus
• Appendix D-2: The Prospects for Immunizing Against Escherichia coli
• Appendix D-3: The Prospects for Immunizing Against Hemophilus influenzae Type b
• Appendix D-4: The Prospects for Immunizing Against Hepatitis A Virus
• Appendix D-5: The Prospects for Immunizing Against Hepatitis B Virus
• Appendix D-6: The Prospects for Immunizing Against Japanese Encephalitis Virus
• Appendix D-7: The Prospects for Immunizing Against Mycobacterium leprae
• Appendix D-8: The Prospects for Immunizing Against Neisseria meningitidis
• Appendix D-9: The Prospects for Immunizing Against Parainfluenza Viruses
• Appendix D-10: The Prospects for Immunizing Against Plasmodium spp.
• Appendix D-11: The Prospects for Immunizing Against Rabies Virus
• Appendix D-12: The Prospects for Immunizing Against Respiratory Syncytial Virus
• Appendix D-13: The Prospects for Immunizing Against Rotavirus
• Appendix D-14: The Prospects for Immunizing Against Salmonella typhi
• Appendix D-15: The Prospects for Immunizing Against Shigella spp.
• Appendix D-16: The Prospects for Immunizing Against Streptococcus Group A
• Appendix D-17: The Prospects for Immunizing Against Streptococcus pneumoniae
• Appendix D-18: The Prospects for Immunizing Against Vibrio cholerae
• Appendix D-19: The Prospects for Immunizing Against Yellow Fever
• Appendix E: Questionnaire for Assessing Morbidity-Mortality Trade-Offs
• Appendix F: Technical Notes
• Appendix G: Biographical Notes on Committee Members
• Appendix H: Additional Sources of Advice to the Committee
• Appendix I: Contents of Supplement to Volume II
• Appendix J: Preface to Volume I
• Appendix K: Contents to Volume I
• Index