Natural Products for Antibacterial Drug Development: Recent Advancement of Computational Approach

The book focuses on the rampant use of higher-dose antibiotics in human routine consumption and how it leads to bacterial resistance to multiple drugs. Book chapters focus on the result of their overuses and concomitant misuses, and how antibiotics have become synonymous with the unending hellish experience that is antimicrobial resistance by pathogenic microbes. It also talks about the challenges associated with the treatment of bacterial infections and challenges to mankind due to the development of high rates of antibiotic resistance. This book also provides information about developments of antibacterial drugs from natural sources. In addition, it also covers different computational approaches used for antibacterial drug development from natural sources in recent times. Finally, the book also elucidates a detailed outline of bacterial resistance status, current treatment methods, natural products as an opportunity for the development of potent druggable candidates, and methods of antibacterial drug development. This book serves as a great resource for students, researchers, and academicians in the field of pharmacology.

Dr. Tripti Sharma currently serves as Professor and Principal at School of Pharmaceutical Sciences and Research, Chhatrapati Shivaji Maharaj University, Panvel, Navi Mumbai, Maharashtra 410221.  She has 19 years of teaching experience in Pharmaceutical Chemistry at undergraduate and postgraduate levels. She has 14 years of research experience in computational drug design, and drug development. During this period, she has been involved in teaching and research. She is a life member of the Association of Pharmaceutical Teachers of India (APTI), Orissa Chemical Society. To her credit, she has more than 45 publications in national and international journals of repute and 9 book chapters. She is serving as a reviewer in various national/international Journals as well.

Dr. Chita Ranjan Sahoo presently availing ICMR-Centenary Post-Doctoral Fellowship (PDF) from ICMR, Department of Health Research, Ministry of Health and Family Welfare, Government of India, and he was received PhD at Central Research Laboratory, Institute of Medical Sciences and SUM Hospital, and Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha.  He obtained his master’s degree in biotechnology, Utkal University, Odisha, India. He has published several research articles, review articles, abstracts, book chapter and books with the leading houses. Moreover, His contribution towards problem to key solution in research achieving Chief Minister Award- for the year 2016-17 as youth innovation, Young Scientist Award in Science-2018, Rajiv Gandhi Prativa Puraskar Odisha Forum and a few more. He has been associated with various professional societies, life member association.

Dr. Debdutta Bhattacharya presently working as Scientist-E at ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Bhubaneswar-751023. He has completed his PhD in Microbiology under Pondicherry University from ICMR-RMRC, Port Blair. He is working with ICMR for last 16 years in various capacities. He is trained in Public Health Microbiology and Infectious Disease Biology. His area of research interest is One Health, Antimicrobial resistance, Infectious Disease Epidemiology and zoonotic disease. He has been part of various outbreak investigation team deputed by Emergency Medical Relief team deputed by Ministry of Health and Family Welfare, Government of India and by the institute. He was involved as a lead scientist from the centre in the development of the 1st Odisha based Antigen detection kit (ImCOV-Ag) in collaboration with IMGENEX India Pvt. Ltd. He has published more than 90 papers in national and international journals of repute on various aspects of infectious diseases. He serves as Editorial panel member of several journals. He is also the recipient of ICMR Gold Medal and Bill and Melinda Gates Foundation Professional Development Award 2022 for his work on Infectious Diseases.

Dr. Sanghamitra Pati presently working as Scientist-G and Director at ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Bhubaneswar-751023. She physician turned laboratory scientist and public health researcher, Dr. Sanghamitra Pati completed her MBBS (1992) and MD (1998) from MKCG Medical College, Berhampur, Odisha, India. She completed her PhD on Multimorbidity in Primary care on 28th June, 2023 from Maastricht University, The Netherlands. In 2000, she received Joint Japan/World Bank Graduate Scholarship (JJ/WBGS) to pursue Master of Public Health (MPH) from University of Maastricht, The Netherlands. Since August 2016, Dr. Pati has been serving as the Director of ICMR-Regional Medical Research Centre, Bhubaneswar for advancing research programs aimed at improvement of public health through addressing different causes of both communicable and non-communicable diseases. Her Wellcome Trust funded research is the first in India and any Low and Middle Income Country to assess the burden and impact of multimorbidity (coexistence of multiple chronic illness in a person) in patients attending health care settings. The MAQ-PC tool developed by her is now being used by many researchers across the LMICs to measure multimorbidity. She has co-authored 280+ scientific publications in the peer-reviewed journals. She has an h-index of 39 and i10-index of 122. Dr. Pati is a fellow of UICC (Union for International Cancer Control) and Indian Public Health Association (IPHA) and a Distinguished Lown Scholar, at Harvard School of Public Health, Boston. She is also the recipient of APACT Young Investigator Award (2007, Taiwan), Early Career Award from International Society of Behavioral Medicine (2010, 2012), and International Engagement Award, by The Wellcome Trust UK (2015-16). In 2021, she was elected as the Fellow of National Academy of Medical Sciences (FAMS), India and Fellow of Royal Society of Public Health (FRSPH) , UK. She is also Fellow Member of Royal Society of Public Health, London, Royal Academy of Medicine, Ireland, International Society of Global Health, Edinburgh, Royal Society of Tropical Medicine and Hygiene, London.