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Inhaltsangabe: Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figures were roughly three times higher. Attenuated measles virus (MV) strains, all quite closely related to the original Edmonston isolate, have a very good record as a safe and highly efficacious vaccine and have brought down the measles toll in industrialized countries to almost negligible levels. However, recent outbreaks in the USA and Europe have again brought the measles problem to public attention. Sadly enough, these outbreaks were more instrumental in inducing activities to drastically reduce and hopefully finally eradicate measles than were the ten thousand times higher number of victims in developing countries. To reach this goal, as detailed in this volume, apparently it is not enough to of the existing vaccine as was the rigorously enforce use case with smallpox eradication: the intricacies of measles disease phenomena, in particular the generalized immune suppression which favors secondary infections, require more basic knowledge of the virus-host interactions and probably the development of new vaccines for special applications such as first immunizations of very young infants in developing countries.
The volume summarizes the state of the art in measles virus research in the area of virology, molecular biology, immunology, and prevention of associated diseases. Measles continues to be one of the leading childhood diseases in the developing world with a high morbidity and mortality. The prevention of measles worldwide requires that we better understand the molecular and biological properties of the virus, the immunologic and immune pathogenic responses to both infection and vaccination, and the epidemiology of measles in different regions of the world as a measure of the success and failure of vaccination strategies.
This volume is intended to catalyze the exchange and collaboration between workers in different disciplines and facilitate the entry of newcomers to this field of resarch.
Titel: Measles Virus Current Topics in Microbiology...
Verlag: New York Berlin, Springer 1995.
Buchbeschreibung New York Berlin, Springer, 1995. 8°, HArdcover. Buchzustand: Gut. first Edition. 196 S. Figures, good Condition Sprache: Englisch Gewicht in Gramm: 1100. Artikel-Nr. 386223