Since 1955, this landmark masterwork has been revered for its authoritative presentation of the entire state of scientific and clinical knowledge about multiple sclerosis. This new edition summarises the state of knowledge on this common neurological disease to mid-2005. No person who aspires to know about multiple sclerosis can do without this book! The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease. Amply illustrated and referenced and beautifully written, McAlpine's Multiple Sclerosis has been described as "A standard reference for multiple sclerosis researchers, embryonic 'MS-ologists' and hard-pressed clinical neurologists alike" (Brain, review of the last edition). Reviews the earliest clinical and pathological descriptions of multiple sclerosis. Offers a very strong section on pathogenesis. Includes more than 550 high-quality illustrations clarifying important scientific and clinical concepts. Uses a remarkably clear presentation to make complicated data as easy as possible to understand. Presents the most recent information on genetics and epidemiology, with an emphasis on clinical relevance. Covers all of the latest approaches to diagnosis and management. Offers new chapters on treatment of the acute relapse, treatment of symptoms, and disease-modifying treatments. Includes contributions from four new world-renowned authors to reflect more international perspectives. Features a new, more user-friendly page design for enhanced ease of reference.

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REVIEWS OF THE LAST EDITION:

"The principal merit of this book is the clear and coherent approach of the six authors, who are the world's leading figures in the field, to describing and interpreting the many complex and variable aspects of multiple sclerosis."―NEJM
" Since its inception, McAlpine's Multiple Sclerosis has achieved the rare distinction of becoming one of the classical neurological texts of the last century. The possession of this book was a priority for anyone practising neurology and a necessary acquisition for any self-respecting medical library."―Brain
"The authors must be warmly congratulated on producing an outstanding reference text that Nigel Compston and his original coauthors would be immensely proud of, their intention at the outset being that of simulating interest 'in the ever widening field of demyelinating disease'. This book clearly fulfils that legacy and definitively presents the current state of knowledge."― J Neurol Neurosurg Psychiatry

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