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What are the main challenges of computational molecular biology once the genome projects are completed? Integrative Approaches to Molecular Biology focuses on molecular biology beyond sequences: from gene regulation to differentiation, a higher-level integration that will be a major theme in biology following conclusion of the genome program. It charts the course of the emerging discipline of integrative molecular biology from macromolecular sequences to a biological (and theoretical) perspective, showing that novel integrative methodologies and paradigms are emerging at the confluence of such disciplines as computer science, logic, linguistics, and mathematics. Following an introductory chapter by Richard Lewontin that offers a critique of the evolutionary process as one of engineering design, the first part of the book, on computational biology, addresses issues concerning protein and DNA sequences within genome projects and a federated infrastructure for databases. The second part brings together experimental, evolutionary, computational, and theoretical approaches dealing with regulation of gene expression, metabolic pathways, and cell differentiation. The book concludes with a chapter on problems and perspectives on artificial intelligence. CONTENTS Preface 1 Evolution as Engineering I Computational Biology 2 Analysis of Bacteriophage T4 Based on the Completed DNA Sequence 3 The Identification of Protein Functional Patterns 4 Comparative Genomics: A New Integrative Biology 5 On Genomes and Cosmologies II Regulation, Metabolism, and Differentiation: Experimental and Theoretical Integration 6 A Kinetic Formalism for Integrative Molecular Biology: Manifestation in Biochemical Systems Theory and Use in Elucidating Design Principles for Gene Circuits 7 Genome Analysis and Global Regulation in Escherichia coli 8 Feedback Loops: The wheels of Regulatory Networks 9 Integrative Representations of the Regulation of Gene Expression 10 Eukaryotic Transcription 11 Analysis of Complex Metabolic Pathways 12 Where Do Biochemical Pathways Lead? 13 Gene Circuits and Their Uses 14 Fallback Positions and Fossils in Gene Regulation 15 The Language of the Genes Glossary References Contributors Index. Printed Pages: 360. Buchnummer des Verkäufers 45410
Titel: Integrative Approaches to Molecular Biology
Verlag: Ane Books Pvt. Ltd/MIT Press
Auflage: First edition.