Integrated View Of Reactive Oxygen Species, Oxidative Stress In Ageing: Basic Mechanism, Functional Effect And Possible Biomarkers

1. Introduction ■ Types of reactive oxygen species (ROS) ■ Sources ■ Structure ■ Mechanism of ROS generation ■ p53,oxidative stress and ROS. 2. Oxidative stress and free radical damage ■ Oxidative lipid damage ■ Oxidative DNA damage ■ Oxidative protein damage ■ Role of ROS in cell signaling ■ Aberrant regulation of redox-sensitive signal pathway ■ Molecular mechanism of age-related diseases. 3. Antioxidant defense ■ Antioxidant therapy ■ Oxidative modification of protein and possible biomarkers. 4. Specific pathways transduced by ROS and ROS-induced apoptosis will provide opportunities to impact both life span, Age related-diseases and design the chemotherapeutics for humans.