Neuware -In recent years there have been various discoveries connecting inflammation and lung cancer and clearly there is growing interest in this area of cancer research.The link between unresolved inflammation and cancer has been well established with estimates that 15% of cancer deaths are inflammation�related. Evidence for this link includes thefollowing: a) some inflammatory diseases are associated with increased risk of cancer development; b) inflammatory mediators are present surrounding and within most tumors; c) overexpression of inflammatory cytokines increases cancer development and progression in murine studies; d) inhibition of inflammatory mediators decreases cancer development and progression; and e) the use of non�steroidal anti�inflammatory drugs (NSAIDs) has been found to decrease cancer incidence and delay progression.The volume will presentaspects of the inflammatory tumor microenvironment (TME), itsmany roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of micr�RNAs (miRNAs) and an increase in a stem cell phenotype. The book will also cover the mechanisms of inflammatory mediators.Chronic overexpression of inflammatory mediators in the TME, as seen in smokers and patients with non�small cell lung cancer (NSCLC), can also lead to increased tumor initiation, progression, invasion and metastasis.The volume will provide a comprehensive perspective ofthe latest findings and summaries of progress made regardinginflammation and its connection tolung cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

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Titel: Inflammation and Lung Cancer
Verlag: Springer New York, Springer US Jun 2015
Erscheinungsjahr: 2015
Sprache: Englisch
ISBN-10: 149392723X
ISBN-13: 9781493927234
Einband: Buch
Zustand: Neu
Abmessungen: Breite: 241 mm, H�he: 160 mm, Tiefe: 17 mm
Gewicht: 506 Gramm

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In recent years there have been various discoveries connecting inflammation and lung cancer and clearly there is growing interest in this area of cancer research. The link between unresolved inflammation and cancer has been well established with estimates that 15% of cancer deaths are inflammation‐related. Evidence for this link includes the following: a) some inflammatory diseases are associated with increased risk of cancer development; b) inflammatory mediators are present surrounding and within most tumors; c) overexpression of inflammatory cytokines increases cancer development and progression in murine studies; d) inhibition of inflammatory mediators decreases cancer development and progression; and e) the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) has been found to decrease cancer incidence and delay progression. The volume will present aspects of the inflammatory tumor microenvironment (TME), its many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of micro‐RNAs (miRNAs) and an increase in a stem cell phenotype. The book will also cover the mechanisms of inflammatory mediators. Chronic overexpression of inflammatory mediators in the TME, as seen in smokers and patients with non‐small cell lung cancer (NSCLC), can also lead to increased tumor initiation, progression, invasion and metastasis. The volume will provide a comprehensive perspective of the latest findings and summaries of progress made regarding inflammation and its connection to lung cancer.

�ber die Autorin bzw. den Autor

Steven M. Dubinett is Professor of Medicine and Pathology at the David Geffen School of Medicine at UCLA, Senior Associate Dean for Translational Research at UCLA, as well as the Director of the UCLA Lung Cancer Research Program. Building on original discoveries relevant to inflammation in the pathogenesis of lung cancer, he has developed a translational research program which now utilizes these laboratory-based discoveries in the translational research. Dr. Dubinett has received continuous peer-reviewed federal funding for translational lung cancer research for more than 20 years.

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