Excitatory Amino Acids and Synaptic Transmission

The excitatory amino acids (EAAs) as neurotransmitters are of vast and rapidly expanding interest. This volume relates current knowledge of the EAAs back to the synapse, where many of their physiologically relevant actions must occur. Excitatory Amino Acids and Synaptic Transmission is the first book to do so.
A multinational team of experts have contributed not only novel, but in some cases, controversial material, reflecting the competition between research groups on both sides of the Atlantic.

Key Features
* Features a complete glossary
* Includes one common reference list
* Useful as a teaching tool for undergraduates and postgraduates
* Can be used as a reference text for experts
* Presents a marriage of up-to-date molecular biology and biophysics with a traditional approach to the function of synapses in the central nervous system

Excitatory amino acids are the transmitters at the vast majority of fast, excitatory synapses within the mammalian central nervous system.
This volume integrates up-to-date molecular biology and biophysics with the traditional approaches of physiology, pharmacology and biochemistry to provide a broad understanding of the role of excitatory amino acids at CNS synapses.
It is intended for all those involved in research in this field and for students of neurobiology who need a comprehensive reference text on the subject. An extensive glossary of terms helps the less expert reader where individual chapters do not permit complete explanations.
The three-dimensional reconstruction of a thalamo-cortical presynaptic bouton [in orange on the front cover, blue mesh on back cover] contacting three postsynaptic targets [dendritic spines, coloured blue on both front and back cover] in visual cortex, was provided by M J Friedlander and K A C Martin with image reconstruction by J Gemmill and D McCarthy. Neurobiology Research Center, University of Alabama at Birmingham. The presynaptic axon was recorded intracellularly, filled with HRP, and the bouton reconstructed from over fifty digitised serial EM sections.
The three-dimensional reconstruction of a hippocampal pyramidal neuron was provided by Howard Wheal.

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