Neuware -This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo.Books on Demand GmbH, �berseering 33, 22297 Hamburg 172 pp. Englisch.

Bestandsnummer des Verk�ufers 9783845402826

Verk�ufer kontaktieren

Diesen Artikel melden

Bibliografische Details

Titel: Development of a new inactivated virus vaccine
Verlag: LAP LAMBERT Academic Publishing Jul 2011
Erscheinungsjahr: 2011
Sprache: Englisch
ISBN-10: 3845402822
ISBN-13: 9783845402826
Einband: Taschenbuch
Zustand: Neu

�ber diesen Titel

Inhaltsangabe

This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo.

Rese�a del editor

��ber diesen Titel� kann sich auf eine andere Ausgabe dieses Titels beziehen.

Anbieterinformationen

Impressum Thorsten Retsch Buchversand Mimpf2000 Ober�lschnitz 16 95517 Emtmannsberg Deutschland Telefon: 09209-2023188 Email: mimpf2000@online.de USt-ID-Nr.: DE 235096871 Wir f�hren gebrauchte B�cher aus allen Sparten der Literatur

Zur Homepage des Verk�ufers

Unternehmensdaten des Verk�ufers

buchversandmimpf2000
Germany

Gesch�ftsbedingungen und Versandinformationen

Verkaufsbedingungen

Widerrufsbelehrung/ Muster-Widerrufsformular/
Allgemeine Gesch�ftsbedingungen und Kundeninformationen/ Datenschutzerkl�rung

Widerrufsrecht f�r Verbraucher
(Verbraucher ist jede nat�rliche Person, die ein Rechtsgesch�ft zu Zwecken abschlie�t, die �berwiegend weder ihrer gewerblichen noch ihrer selbstst�ndigen beruflichen T�tigkeit zugerechnet werden k�nnen.)

Widerrufsbelehrung

Widerrufsrecht
Sie haben das Recht, binnen 14 Tagen ohne Angabe von Gr�nden diesen Vertrag zu widerrufen.
Die Widerrufsfr...

Mehr Information

Versandbedingungen

Soweit in der Artikelbeschreibung keine andere Frist angegeben ist, erfolgt die Lieferung der Ware innerhalb von 3-5 Werktagen nach Vertragsschluss, bei Vorauszahlung erst nach Eingang des vollst�ndigen Kaufpreises und der Versandkosten. Alle Preise inkl. MwSt.

Impressum & Info zum Verk�ufer