Conducting and Interpreting Clinical Trials in Heart Failure: An Issue of Heart Failure Clinics

This issue of Heart Failure Clinics is dedicated to an in-depth analysis of the conduct of clinical investigation in patients with acute decompensated heart failure (ADHF). It tackles the difficult questions involved in patient population, trial conduct, surrogate endpoints, clinical endpoints, and statistical considerations.  The purpose of the issue is to provide information that will be meaningful and useful to help physicians in thinking about the design of clinical trials in this field.