Computational and Structural Approaches to Drug Discovery : Ligand-Protein Interactions. Dieser Artikel ist nicht verfügbar.Computational and Structural Approaches to Drug Discovery : Ligand-Protein Interactions

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials. This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. Addressing a wide range of uses of protein structures for drug discovery, the Editors have created an essential reference for professionals in the pharmaceutical industry and a core text for all graduate level courses covering molecular interactions and drug discovery.

Robert M. Stroud is a professor at the University of California and has been a fellow of the Royal Society of Medicine (UK) since 1992 and a member of the National Academt of Sciences (US) since 2003. His prestigious career spans over 35 years and he is and has served on the scientific advisory boards of many companies and institutions including the National Cancer Institute, the Neutron Diffraction facility, Axys Pharmaceuticals, and Sunesis Phamraceuticals. Janet Finer-Moore is a Research Biologist at the University of California Her contribution to the detailed determination of the structural and chemical mechanism of a two substrate enzyme and detection of amphipathic helices in protein and gene sequences have perpetuated over 28 publications. She is a member of the AAAS, the ACA, the ACS and the Biophysical Society.