This volume contains a selection of the best contributions delivered at the 5th InternationalMeetingonComputationalIntelligenceMethodsforBioinformatics andBiostatistics(CIBB 2008)held atIIASS "E. R. Caianiello",Vietri sul Mare, Salerno, Italy during October 3-4, 2008. The CIBB meeting series is organized by the Special Interest Group on Bioinformatics of the International Neural Network Society (INNS) to provide a forum open to researchersfrom di?erent disciplines to present and discuss pr- lems concerning computational techniques in bioinformatics, systems biology and medical informatics with a particular focus on neural networks, machine learning, fuzzy logic, and evolutionary computational methods. Previous CIBB meetings were held with an increasing number of participants within the f- mat of a special session of larger conferences, namely, WIRN 2004 in Perugia, WILF 2005 in Crema, FLINS 2006 in Genoa and WILF 2007 in Camogli. Given the great success of the special session at WILF 2007 that included 26 papers after a strong selection, the 2008 edition of CIBB was organized, at last, as an autonomous conference, governed by its own Steering Committee. CIBB 2008 attracted 69 paper submissions from all over the world. A r- orous peer-review selection process was applied to ultimately select the papers included in the program of the conference. This volume collects the best cont- butions presented at the conference. Moreover, the volume also includes three presentations from keynote speakers. The success of this conference is to be credited to the contribution of many people.

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This book constitutes the thoroughly refereed post-conference proceedings of the Fifth International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2008, held in Vietri sul Mare, Italy, in October 2008.

The 23 revised full papers presented together with 3 invited lectures were carefully reviewed and selected from 69 submissions. The main goal of the CIBB meetings is to provide a forum open to researchers from different disciplines to present and discuss problems concerning computational techniques in bioinformatics, systems biology and medical informatics with a particular focus on neural networks, machine learning, fuzzy logic, and evolutionary computation methods.

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