Biomedical Photonics Handbook: Biomedical Diagnostics

Shaped by Quantum Theory, Technology, and the Genomics Revolution

The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside.

Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies.

A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition contains new topics and chapters including:

• Fiber Optic Probe Design

• Laser and Optical Radiation Safety

• Photothermal Detection

• Multidimensional Fluorescence Imaging

• Surface Plasmon Resonance Imaging

• Molecular Contrast Optical Coherence Tomography

• Multiscale Photoacoustics

• Polarized Light for Medical Diagnostics

• Quantitative Diffuse Reflectance Imaging

• Interferometric Light Scattering

• Nonlinear Interferometric Vibrational Imaging

• Multimodality Theranostics Nanoplatforms

• Nanoscintillator-Based Therapy

• SERS Molecular Sentinel Nanoprobes

• Plasmonic Coupling Interference Nanoprobes

Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and lists of references for further reading.

Tuan Vo-Dinh is the R. Eugene and Susie E. Goodson Distinguished Professor of biomedical engineering, professor of chemistry, and director of the Fitzpatrick Institute for Photonics at Duke University. He received a B.S. in physics in 1970 from EPFL (Ecole Polytechnique Federal de Lausanne) in Lausanne and a Ph.D. in physical chemistry in 1975 from ETH (Swiss Federal Institute of Technology) in Zurich, Switzerland. Dr. Vo-Dinh has authored over 350 publications in peer-reviewed scientific journals. He is the author of a textbook on spectroscopy and editor of 6 books. He has received numerous awards and holds over 37 U.S. and international patents.