Biochemical Studies of ACTH and cortisol in Type 1 Diabetic females

Diabetes mellitus, can cause various endocrine disorders by affecting the secretion, metabolism, clearance or bioavailability of hormones. We investigated changes in (ACTH) and (cortisol) in Iraqi females with type 1 diabetes. Increased activity of the hypothalamus-pituitary-adrenal cortex (HPA) axis resulting enhanced adrenocorticotropin (ACTH) and serum glucocorticoid level. So the determining ACTH and cortisol level could be considered as a marker for progresses of diabetes and other complication associated with DM1 like cushing syndrome.