Aquasome Based Drug Delivery: Development And Evaluation Of Aquasomes

Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. Alternatively aquasomes are called as “bodies of water”, their water like properties protect and preserve fragile biological molecules, and this property of maintaining conformational integrity as well as high degree of surface exposure are exploited in targeting of bio-active molecules like peptide and protein hormones, antigens and genes to specific sites. These carbohydrate stabilize nanoparticles of ceramic are known as “aquasomes” which was first developed by Nir Kossovsky. The pharmacologically active molecule incorporated by co-polymerization, diffusion or adsorption to carbohydrate surface of pre formed nanoparticles. Nanotechnology offers some new solutions in treating various diseases.