Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded.Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated.

Cr�ticas:

`Every once in a while, one finds a text that is likely to be truly useful and a valuable addition to one's personal library. For those of us involved in cardiovascular research involving the use of whole animal models, such is this text.
Each chapter is prefaced with information of practical value for the researcher. The tables are subdivided by animal species and drug. ... This will be of tremendous value for anybody who is thinking about using a particular animal model for a research project and may save a good deal of time and effort.
For those of us who review grants and manuscripts for publication, this text should serve as a useful reference for normal values and for comparative studies so as to determine whether or not the work in question reflects a typical situation.
... the text is likely to be of considerable use and is highly recommended as an addition to the bookshelves of those of us involved in animal research. It will receive a prominent place in my library.'
Canadian Journal of Anaesthesia, 42:4 (1995)

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