Neuware -The three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 124 pp. Englisch.

Bestandsnummer des Verk�ufers 9783031059162

Verk�ufer kontaktieren

Diesen Artikel melden

Bibliografische Details

Titel: Algorithms and Methods in Structural Bioinformatics
Verlag: Springer International Publishing, Springer International Publishing Sep 2023
Erscheinungsjahr: 2023
Sprache: Englisch
ISBN-10: 3031059166
ISBN-13: 9783031059162
Einband: Taschenbuch
Zustand: Neu

�ber diesen Titel

Inhaltsangabe

The three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved.

In this book we focus on a number of topics in Structural Bioinformatics: Cryo-EM structural detection, protein conformational exploration, elucidation of molecular binding surface using geometry, the effect of mutations, insertions and deletions on protein structural stability, and protein-ligand binding.

�ber die Autorin bzw. den Autor

Nurit Haspel has been a member of the Department of Computer Science at the University of Massachusetts, Boston since 2009. She received her Ph.D. from Tel Aviv University in 2007. Her research lies in the areas of computational structural biology and structural bioinformatics. Her goal is to better understand the structure and flexibility of proteins, to model conformational changes in proteins, and to model protein-protein interactions. In her research, she focuses on both the development of novel algorithms and the application of state-of-the-art existing methodologies to various problems in molecular biology and biochemistry.
Filip Jagodzinski joined the faculty of Western Washington University in 2015. He earned his Ph.D. from the University of Massachusetts, Amherst in 2012, and his MS from Villanova and BS from Columbia University. With his undergraduate and graduate students, and in coordination with Machine Learning and biology and chemistrycollaborators, Filip develops computational recipes for predicting the structural properties of disease-causing protein mutants and inferring the effects of indels. Their tools are often disseminated via web servers or as open-source software.Kevin Molloy joined the faculty at James Madison University in 2018. He earned his Ph.D. from George Mason University in 2015, his MS from George Mason in 2011, and his BS from George Mason in 1998. His research focuses on studying the flexibility of protein systems and the role this flexibility plays in their function, specifically in antimicrobial peptides. He is also developing algorithms to characterize the structural rearrangements that proteins undertake to fluctuate their functional roles and how amino acid sequence mutations impact these transitions.

��ber diesen Titel� kann sich auf eine andere Ausgabe dieses Titels beziehen.

Anbieterinformationen

Impressum Thorsten Retsch Buchversand Mimpf2000 Ober�lschnitz 16 95517 Emtmannsberg Deutschland Telefon: 09209-2023188 Email: mimpf2000@online.de USt-ID-Nr.: DE 235096871 Wir f�hren gebrauchte B�cher aus allen Sparten der Literatur

Zur Homepage des Verk�ufers

Unternehmensdaten des Verk�ufers

buchversandmimpf2000
Germany

Gesch�ftsbedingungen und Versandinformationen

Verkaufsbedingungen

Widerrufsbelehrung/ Muster-Widerrufsformular/
Allgemeine Gesch�ftsbedingungen und Kundeninformationen/ Datenschutzerkl�rung

Widerrufsrecht f�r Verbraucher
(Verbraucher ist jede nat�rliche Person, die ein Rechtsgesch�ft zu Zwecken abschlie�t, die �berwiegend weder ihrer gewerblichen noch ihrer selbstst�ndigen beruflichen T�tigkeit zugerechnet werden k�nnen.)

Widerrufsbelehrung

Widerrufsrecht
Sie haben das Recht, binnen 14 Tagen ohne Angabe von Gr�nden diesen Vertrag zu widerrufen.
Die Widerrufsfr...

Mehr Information

Versandbedingungen

Soweit in der Artikelbeschreibung keine andere Frist angegeben ist, erfolgt die Lieferung der Ware innerhalb von 3-5 Werktagen nach Vertragsschluss, bei Vorauszahlung erst nach Eingang des vollst�ndigen Kaufpreises und der Versandkosten. Alle Preise inkl. MwSt.

Impressum & Info zum Verk�ufer