Advances in Peptic Ulcer Pathogenesis

Beschreibung

Druck auf Anfrage Neuware - Printed after ordering - Over the past decade a great deal of research activity has occurred on either side of the gastroduodenal epithelial interface, with the common goal of elucidating the mechanisms of mucosal protection and how these may be compromised in peptic ulcer disease. A prime stimulus to such research has been the realization that abnormal acid secretion or its delivery into the duodenum in excessive amount cannot fully explain ulcer pathogenesis in the majority of patients. One may envisage the stomach and proximal duodenum as being in a dynamic equilibrium, with aggressive luminal factors, such as acid and pepsin, being counteracted by protective mucosal mechanisms. Until recently, the mechanisms involved in mucosal protection had been poorly defined while the physiology and pathophysiology of acid and pepsin secretion had been elucidated. The impression that gastroduodenal mucosa was protected by a single mechanism has at last been replaced by a more realistic view, suggesting a number of protective zones acting in series. Some of these zones may act as first or second line defences against aggressive factors while certain zones may specifically protect against certain aggressors.

Bestandsnummer des Verkäufers 9789401070522

Verkäufer kontaktieren

Diesen Artikel melden

Bibliografische Details

Titel

Advances in Peptic Ulcer Pathogenesis

Verlag

Springer Netherlands

Veröffentlichungsdatum

2011

Sprache

Englisch

ISBN-10

9401070520

ISBN-13

9789401070522

Bindung

Taschenbuch

Zustand

Neu

Über diesen Titel