Chemical Exchange Saturation Transfer Imaging: Advances and Applications - Hardcover

"This textbook is very helpful for those who are eager to fully understand the principles and development of chemical exchange saturation transfer (CEST) techniques. One strength of this book is in the discussion of probes, and another strength is having Sture Forsén and Robert Balaban describe their early studies. This book will have a great impact promoting the clinical translation of CEST imaging."

―Prof. Renhua Wu, Shantou University, China

"This book presents an in-depth and comprehensive description of CEST physics, techniques, and applications. It is in time for the dawn of label-free molecular imaging that explores chemical exchange phenomena the nature offers. It is also a collection of very updated perspectives of the future of CEST magnetic resonance imaging (MRI), quite informative, and fun to read for imaging physicists, radiologists, and clinician scientists."

―Prof. Ed X. Wu, The University of Hong Kong, Hong Kong

"This is an excellent book on CEST MRI with state-of-the-art chapters from thought leaders in the field. It touches on all aspects of CEST: image acquisition methods and data processing, development of exogenous CEST probes, and applications of CEST in clinical and biomedical imaging. A very valuable addition to biomedical imaging canon, and a text that will be beneficial to students and experts alike."

―Prof. Peter Caravan, Harvard Medical School, USA

"This book has been edited by faculty from one of the leading centers with extensive experience of chemical exchange saturation transfer (CEST) MRI and is the first to focus exclusively on this specific imaging technique. The authors include many of the leaders in the field, and it belongs on the shelf of anyone seriously involved in CEST work. It has broad breadth of coverage which makes it a go-to reference for overviews of many sub-specialty applications. It is clearly valuable as a standard in the field and I expect it will serve as the essential starting point for in-coming graduate students beginning CEST research and for established researchers delving into a new area."

―Dr. Daniel F. Gochberg, Vanderbilt University Institute of Imaging Science, USA

"Chemical exchange saturation transfer (CEST) can be used to detect proteins, peptides, metabolites, and probe molecules in 1H MR images of tissue water, with observation via the water resonance massively increasing the sensitivity of their detection. This timely book describes the history of the technique’s development and the underlying theory and then goes on to review its latest applications. It is a comprehensive and insightful book written by the leaders in the field. It is a must read book for anyone already in the CEST field, or thinking of entering the field and, given the growing popularity of the methods described here, should be read by anybody working in the field of in vivo MR."

―Prof. Kevin Brindle, University of Cambridge, UK, Molecular Imaging and Biology, 2017

This is the first textbook dedicated to CEST imaging and covers the fundamental principles of saturation transfer, key features of CEST agents that enable the production of imaging contrast, and practical aspects of preparing image-acquisition and post-processing schemes suited for in vivo applications. CEST is a powerful MRI contrast mechanism with unique features, and the rapid expansion it has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical, translational, and clinical CEST imaging. The book provides an illustrated historical perspective by leaders at the five key sites who developed CEST imaging, from the initial saturation transfer NMR experiments performed in the 1960s in Stockholm, Sweden, described by Sture Forsén, to the work on integrating the basic principles of CEST into imaging by Robert Balaban, Dean Sherry, Silvio Aime, and Peter van Zijl in the United States and Italy.

The editors, Drs. Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte, and Peter C. M. van Zijl, have been pioneers developing this field at the Johns Hopkins University School of Medicine and the Kennedy Krieger Institute including contributions to Nature Medicine, Nature Biotechnology, Nature Materials, and the Proceedings of the National Academy of Sciences. As recognition for their initial development of the field, Drs. van Zijl and Balaban were awarded the Laukien Prize in April 2016, established in 1999 to honor the memory of Professor Gunther Laukien, a co-founder of Bruker Biospin GmbH.