One-Step Generation of a Drug-Releasing Microarray for High-Throughput Small-Volume Bioassays (Springer Theses) - Softcover

Buch 601 von 797: Springer Theses

Song, Seo Woo

 
9789811380969: One-Step Generation of a Drug-Releasing Microarray for High-Throughput Small-Volume Bioassays (Springer Theses)
Softcover
ISBN 10: 9811380961 ISBN 13: 9789811380969
Verlag: Springer, 2020

Inhaltsangabe

This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients’ primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine.

In this thesis, the author firstly describes the need and concept of ‘partipetting’ for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, andrealization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.

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Über die Autorin bzw. den Autor

Seo Woo Song earned PhD degree in the department of electrical and computer engineering from Seoul National University, Republic of Korea in 2019. His research interests are lab on a chip, bioMEMS, and micro-robotics.

Von der hinteren Coverseite

This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients’ primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine.
In this thesis, the author firstly describes the need and concept of ‘partipetting’ for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication,and realization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.

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Verlag
Springer
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
9811380961
ISBN 13 
9789811380969
Einband
Taschenbuch
Auflage
1
Anzahl der Seiten
76
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Weitere beliebte Ausgaben desselben Titels

9789811380938: One-Step Generation of a Drug-Releasing Microarray for High-Throughput Small-Volume Bioassays (Springer Theses)

Vorgestellte Ausgabe

ISBN 10:  9811380937 ISBN 13:  9789811380938
Verlag: Springer, 2019
Hardcover