Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses) - Hardcover

Jin, Wenfei

 
9789401774062: Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses)
Hardcover
ISBN 10: 9401774064 ISBN 13: 9789401774062
Verlag: Springer-Verlag GmbH, 2015

Inhaltsangabe

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

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Über die Autorin bzw. den Autor

Wenfei Jin obtained his Ph.D. from Shanghai Institute of Biological Sciences (SIBS), Chinese Academy of Sciences (CAS). He was supervised by Prof. Li Jin from Fudan University and Prof. Shuhua Xu from SIBS. During his Ph.D. study, Wenfei Jin published 11 research articles, of which 6 articles are as first or co-first author. He received SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards from Eli Lilly, China, in 2012, and won the Excellent Doctoral Dissertation of CAS in 2013. Dr. Wenfei Jin is now a visiting fellow at NHLBI, National Institute of Health in the USA.

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In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

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Verlag
Springer-Verlag GmbH
Erscheinungsdatum
2015
Sprache
Englisch
ISBN 10 
9401774064
ISBN 13 
9789401774062
Einband
Tapa dura
Auflage
1
Anzahl der Seiten
136
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
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9789402404302: Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses)

Vorgestellte Ausgabe

ISBN 10:  9402404309 ISBN 13:  9789402404302
Verlag: Springer, 2016
Softcover