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New method development and validation of sensitive LC-MS/MS method: for Quantification of nitrosoamine impurities in Glimepride active ingredient - Softcover
Inhaltsangabe
The analysis of nitrosoamine impurities using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a critical process in pharmaceutical and food safety testing. Nitrosoamines are known for their potential carcinogenic properties, making their detection and quantification essential. LC-MS/MS offers high sensitivity and specificity, allowing for the effective separation and identification of these compounds in complex matrices. The methodology typically involves sample preparation, which may include extraction and purification steps to isolate nitrosoamines from the sample matrix. Following this, the samples are subjected to LC-MS/MS, where the liquid chromatography component separates the nitrosoamines based on their chemical properties, while the tandem mass spectrometry provides precise mass-to-charge ratio measurements, enabling accurate identification and quantification. Key insights from recent studies indicate that optimizing the chromatographic conditions, such as the choice of stationary phase and mobile phase composition, significantly enhances the resolution and sensitivity of the analysis.
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Über die Autorin bzw. den Autor
K.V.V. Prasad is an analytical chemistry expert with 2 years of experience working in GLP-accredited laboratories and NABL-accredited CRO companies. He is associated with Isosphere Biosciences Private Limited, a contract research organization (CRO) located in Secunderabad, Telangana, that specializes in analytical chemistry and Residue studies.
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New method development and validation of sensitive LC-MS/MS method for Quantification of nitrosoamine impurities in Glimepride active ingredient
Verlag:
LAP LAMBERT Academic Publishing, 2026
ISBN 10: 663025810X
ISBN 13: 9786630258103
Neu
Softcover/Taschenbuch
Anbieter: Home-set, Mannheim, Deutschland
Verkäuferbewertung 5 von 5 Sternen
Softcover/Taschenbuch. Zustand: Neu. The analysis of nitrosoamine impurities using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a critical process in pharmaceutical and food safety testing. Nitrosoamines are known for their potential carcinogenic properties, making their detection and quantification essential. LC-MS/MS offers high sensitivity and specificity, allowing for the effective separation and identification of these compounds in complex matrices. The methodology typically involves sample preparation, which may include extraction and purification steps to isolate nitrosoamines from the sample matrix. Following this, the samples are subjected to LC-MS/MS, where the liquid chromatography component separates the nitrosoamines based on their chemical properties, while the tandem mass spectrometry provides precise mass-to-charge ratio measurements, enabling accurate identification and quantification. Key insights from recent studies indicate that optimizing the chromatographic conditions, such as the choice of stationary phase and mobile phase composition, significantly enhances the resolution and sensitivity of the analysis. Sprache: Englisch Gewicht in Gramm: 119. Artikel-Nr. IB-220845
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