THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NK CELLS: THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NATURAL KILLER (NK) CELLS - Softcover

Lima Da Silva, Maria Aparecida; Amorin, Bruna; Pezzi, Annelise

 
9786206944973: THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NK CELLS: THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NATURAL KILLER (NK) CELLS

Inhaltsangabe

Infusions of T cells and NK cells (Natural Killer) from peripheral blood are being carried out to treat malignancies. Lymphocytes propagated ex vivo, in normoxia (20% O2), are infused intravenously and must survive the hypoxia associated with venous circulation, bone marrow (5% O2) and the tumor microenvironment (1% O2). The main objective of this study was to determine the proliferative capacity of human T and NK cells in normoxia (20% O2) versus hypoxia (1% O2), for 28 days, using an artificial antigen-presenting cell (aAPC) for clinical grade propagation.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Über die Autorin bzw. den Autor

Licenciado en Biología por la PUCRS. Especialización en Biología Molecular Aplicada al Área de la Salud por la ULBRA y Maestría por el Programa de Postgrado en Medicina de la UFRGS. Doctorado sándwich en la Universidad de Texas/MDAnderson Cancer y Postdoctorado en el Laboratorio de Señalización y Plasticidad Celular/UFRGS.

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.