Multicomponent synthesis of 4H-pyran-3-carboxylate derivatives - Softcover

Patel, Dhaval B.

 
9786206151517: Multicomponent synthesis of 4H-pyran-3-carboxylate derivatives

Inhaltsangabe

A simple, versatile, one-pot, multi-component reaction (MCR) of ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives has been achieved in the presence of urea as a potent catalyst in water-ethanol as a green solvent system. Reaction was proceeding via three component reaction by utilizing various aldehyde, malononitrile and ethylacetoacetate at room temperature. All Synthesized products were confirmed by Mass, 1H-NMR, IR and Melting point. Mild reaction conditions, excellent yields, easy isolation of products, no column chromatographic separation, reusability of reaction media.

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