Drug-excipient-shell interactions using thermoplastic capsules - Softcover

Misic, Zdravka; Kuentz, Martin; Imanidis, Georgios

 
9786202007146: Drug-excipient-shell interactions using thermoplastic capsules

Inhaltsangabe

This book introduced novel starch-based thermoplastic capsules (S-PVA-Cs) and demonstrated their advantage over SGCs with respect to hydrophilic lipid-based formulations. Release studies in biorelevant media revealed differences in how formulations hydrated and interacted with the shell material. Drug-excipient-shell interactions were observed in various capsule types (SGCs, S-PVA-Cs, and VegaGels®) at different levels of biopharmaceutical in vitro testing. A better mechanistic understanding was attained that may guide future development of soft capsule products.

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Über die Autorin bzw. den Autor

Zdravka Misic, Croatian national, holds a PhD in Pharmaceutical Sciences from University of Basel, Switzerland. She started her carrier as formulation scientist in Teva in 2004. In 2009 she moved to Switzerland to ETH Zürich as ESKAS scholarship holder. Since 2014, she works successfully on new delivery systems for vitamins in DSM, Switzerland.

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