Inhaltsangabe
The present study was to maintain the levels of diltiazem hydrochloride within a desired range, reduction in its dosing frequency and increase bioavailability. The tablets were formulated by using of 32 factorial design, the effect of independent variables X1 (concentration of hydroxy propyl methylcellulose K100) and X2 (concentration of sodium carboxymethylcellulose) on swelling index and drug release was studied. Tablets were prepared by direct compression method using 13 mm punch on rotary tablet machine. Physical properties of compressed tablets such as hardness, friability, content uniformity, swelling index were determined. The swelling index of optimized batch varied between 114.21 and 220.41 %. The percentage drug release of optimized batch was 15.60% at 1 h and 71.97% at 12 h. From the drug release kinetic study, Peppas model was found to be best fit. Infrared spectrum showed that there was no interaction between drug and polymers in the formulation. The sustained drug release pattern was successfully achieved through the formulation of expandable gastroretentive tablets.
Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.
Über die Autorin bzw. den Autor
O Dr. Anilkumar J. Shinde, M.Pharm Ph.D (Farmácia) tem 26 anos de experiência no ensino e na investigação. Atualmente, trabalha como Professor Associado no Departamento de Farmácia da Faculdade de Farmácia Bharati Vidyapeeth, Kolhapur. Tem 66 trabalhos de investigação e 5 artigos de revisão publicados em revistas nacionais e internacionais. Uma patente nigeriana.
„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.
Suchergebnisse für FORMULATION AND EVALUATION OF EXPANDABLE GASTRORETENTIVE...
Foto des Verkäufers
FORMULATION AND EVALUATION OF EXPANDABLE GASTRORETENTIVE TABLET
Verlag:
LAP LAMBERT Academic Publishing Apr 2022, 2022
ISBN 10: 6200276544
ISBN 13: 9786200276544
Neu
Taschenbuch
Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland
Verkäuferbewertung 5 von 5 Sternen
Taschenbuch. Zustand: Neu. Neuware -The present study was to maintain the levels of diltiazem hydrochloride within a desired range, reduction in its dosing frequency and increase bioavailability. The tablets were formulated by using of 32 factorial design, the effect of independent variables X1 (concentration of hydroxy propyl methylcellulose K100) and X2 (concentration of sodium carboxymethylcellulose) on swelling index and drug release was studied. Tablets were prepared by direct compression method using 13 mm punch on rotary tablet machine. Physical properties of compressed tablets such as hardness, friability, content uniformity, swelling index were determined. The swelling index of optimized batch varied between 114.21 and 220.41 %. The percentage drug release of optimized batch was 15.60% at 1 h and 71.97% at 12 h. From the drug release kinetic study, Peppas model was found to be best fit. Infrared spectrum showed that there was no interaction between drug and polymers in the formulation. The sustained drug release pattern was successfully achieved through the formulation of expandable gastroretentive tablets.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Englisch. Artikel-Nr. 9786200276544
Neu kaufen
EUR 43,90
EUR 60,00 shipping
Versand von Deutschland nach USA
Versand von Deutschland nach USA
Anzahl: 2 verfügbar