Chemotherapy still contributes very little to the five year survival rate of solid cancers. Changing the strategy of how to treat solid cancers could change the success rate significantly. While cell death-inducing agents (so-called “chemotherapeutica”) and combinations thereof are still the first line treatment in oncology, another strategy to achieve selective cancer cell death is to simultaneously deplete glutamine, pyruvate and oxaloacetate in vivo with or without using “chemotherapeutica”. While it is known for many years that tumor cells are addicted to glucose, addiction to glutamine is also known for quite a while but there is little effort to use glutamine-addiction for treating cancers. This is only a basic communication illustrating some aspects of glutamine-metabolism and also of chemotherapeutic options of how to interfere with it. However, it may interest more cancer-treating doctors. Maybe it will improve the success rate of treating solid tumors.
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Rainer Schäfer PhD Dr.med., trained in Biomedi-cal Science at Curtin University of Technology in Western Australia. Since 2005 he develops new strategies improving the success rate against cancers and the pain associated with it. Focusing on differences in cellular signaling in cancers, he applies treatments to cancer patients inhibiting the mutated signaling-pathways in a combined fashion. Dr. Dr. Schäfer uses his expertise as a pain specialist and anaesthetist to treat neuropathic pain in cancers with derivates of capsaicin, a technique that seriously increases quality of life of cancer patients and other chronic pain patients.
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