SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS: Phase Behavior and Click Chemistry of Multi-Responsive Polymeric Microgel Dispersions - Softcover

Meng, Zhiyong

 
9783838387109: SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS: Phase Behavior and Click Chemistry of Multi-Responsive Polymeric Microgel Dispersions
Softcover
ISBN 10: 3838387104 ISBN 13: 9783838387109
Verlag: LAP LAMBERT Academic Publishing, 2010

Inhaltsangabe

Microgels are sub-micron to micron-size polymeric networks confined in limited space swollen by a good solvent, also called hydrogel microparticles or microspheres if swollen in water. Among all microgels investigated nowadays, poly(N-isopropylacrylamide), pNIPAm, microgels are one of the most extensively studied microgel particles due to their volume phase transition (VPT) at lower critical solution temperature (LCST). By incorporation of pH-responsive monomer, acrylic acid (AAc), copolymeric pNIPAm-AAc microgels further demonstrate multi-responsivity to temperature, pH, and ionic strength. A temperature-programmed polymerization protocol is proposed for the synthesis of large pNIPAm-AAc microgel particles with a hydrodynamic diameter of 2~5 ?m. Futhermore, to observe the phase behavior of pNIPAm-AAc microgel dispersions, pNIPAm-AAc dispersions at various pH values and concentrations were allowed to age and undergo phase transition in closed system. Finally, the Cu(I)-catalyzed azide-terminal alkyne 1,3-dipolar cycloaddition, also called Sharpless-Meldal ?click? reaction, is used to functionalize pNIPAm-AAc microgel particles for microgel bioconjugation and medical applications.

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Reseña del editor

Microgels are sub-micron to micron-size polymeric networks confined in limited space swollen by a good solvent, also called hydrogel microparticles or microspheres if swollen in water. Among all microgels investigated nowadays, poly(N-isopropylacrylamide), pNIPAm, microgels are one of the most extensively studied microgel particles due to their volume phase transition (VPT) at lower critical solution temperature (LCST). By incorporation of pH-responsive monomer, acrylic acid (AAc), copolymeric pNIPAm-AAc microgels further demonstrate multi-responsivity to temperature, pH, and ionic strength. A temperature-programmed polymerization protocol is proposed for the synthesis of large pNIPAm-AAc microgel particles with a hydrodynamic diameter of 2~5 μm. Futhermore, to observe the phase behavior of pNIPAm-AAc microgel dispersions, pNIPAm-AAc dispersions at various pH values and concentrations were allowed to age and undergo phase transition in closed system. Finally, the Cu(I)-catalyzed azide-terminal alkyne 1,3-dipolar cycloaddition, also called Sharpless-Meldal "click" reaction, is used to functionalize pNIPAm-AAc microgel particles for microgel bioconjugation and medical applications.

Biografía del autor

Zhiyong Meng, PhD: He studied phase behavior and click chemistry of polymeric microgels at Georgia Tech. His research interests cover polymer synthesis, multi-responsive hydrogels/microgels, aggregation of colloidal particles, and microfluidics. He is currently a postdoctoral associate working with Professor Menachem Elimelech at Yale University.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2010
Sprache
Englisch
ISBN 10 
3838387104
ISBN 13 
9783838387109
Einband
Tapa blanda
Anzahl der Seiten
172
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Verantwortliche Person
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