The objective of this research was to investigate the role of opioids in myocardial protection of the large mammalian heart. A porcine isolated working heart model of swine was carefully characterized and various opioid agonists were administered prior to inducing global ischemia. An acute coronary occlusion model was developed to investigate the effects of opioid preconditioning on regional ischemia, in particular infarct size, myocardial function, and arrhythmias. The results of these studies suggest a specific role of δ-receptor agonists in myocardial protection in large mammalian hearts.
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The objective of this research was to investigate the role of opioids in myocardial protection of the large mammalian heart. A porcine isolated working heart model of swine was carefully characterized and various opioid agonists were administered prior to inducing global ischemia. An acute coronary occlusion model was developed to investigate the effects of opioid preconditioning on regional ischemia, in particular infarct size, myocardial function, and arrhythmias. The results of these studies suggest a specific role of δ-receptor agonists in myocardial protection in large mammalian hearts.
Daniel obtained his M.D. degree from the University of Basel,Switzerland. After getting board-certified in Anesthesia, hecompleted graduate studies in Physiology with a Ph.D. at theUniversity of Minnesota. He lives in Saint Paul, MN, with hisfamily, and currently works in medical research and consulting.
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Taschenbuch. Zustand: Neu. Neuware -The objective of this research was to investigate the role of opioids in myocardial protection of the large mammalian heart. A porcine isolated working heart model of swine was carefully characterized and various opioid agonists were administered prior to inducing global ischemia. An acute coronary occlusion model was developed to investigate the effects of opioid preconditioning on regional ischemia, in particular infarct size, myocardial function, and arrhythmias. The results of these studies suggest a specific role of ¿-receptor agonists in myocardial protection in large mammalian hearts.Books on Demand GmbH, Überseering 33, 22297 Hamburg 208 pp. Englisch. Artikel-Nr. 9783838353791
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Taschenbuch. Zustand: Neu. Pharmacological Preconditioning with Opioids for Myocardial Protection | Role of Delta-Opioid Receptor Agonists | Daniel Sigg | Taschenbuch | 208 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838353791 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Artikel-Nr. 101216148
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