Verwandte Artikel zu Modelling Proteasome Dynamics in a Bayesian Framework...

Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters) - Softcover

Buch 53 von 91: BestMasters

Stübler, Sabine

 
9783658201661: Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters)
Softcover
ISBN 10: 3658201665 ISBN 13: 9783658201661
Verlag: Springer Spektrum, 2017

Inhaltsangabe

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Über die Autorin bzw. den Autor

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Von der hinteren Coverseite

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

Contents
  • Structure and Function of the Proteasome
  • Approaches to Model Proteasome Dynamics
  • Comparison of the Dynamics of Proteasome Subtypes
  • Inhibitor Influence on the CatalyticSubunits
  • Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model
Target Groups
  • Lecturers and students of systems biology, immunology and cell biology
  • Practitioners from the fields of systems biology, immunology and cell biology
About the Author
Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.

Verlag
Springer Spektrum
Erscheinungsdatum
2017
Sprache
Englisch
ISBN 10 
3658201665
ISBN 13 
9783658201661
Einband
Taschenbuch
Auflage
1
Anzahl der Seiten
112
Kontakt zum Hersteller
Springer Nature Customer Service Center GmbH
ProductSafety@springernature.com

Europaplatz 3
Heidelberg
69115
Deutschland

Weitere beliebte Ausgaben desselben Titels

9783658201685: Modelling Proteasome Dynamics in a Bayesian Framework

Vorgestellte Ausgabe

ISBN 10:  3658201681 ISBN 13:  9783658201685
Verlag: Springer Spektrum, 2017
Softcover