A Guide to Bone Marrow Transplantation - Softcover

Deeg, Hans-Joachim Joachim; Klingemann, Hans-Georg; Phillips, Gordon L.

 
9783642970795: A Guide to Bone Marrow Transplantation
Softcover
ISBN 10: 3642970796 ISBN 13: 9783642970795
Verlag: Springer, 2012

Inhaltsangabe

In the late 1940s investigators observed that mice given supralethai doses of total body irradiation were protected by infusion of viable spleen or marrow cells following irradiation, and that this was accomplished by hemopoietic reconsti­ tution with donor cells as proven using genetic markers. If a similar approach could be applied to humans, it should be possible to treat leukemia patients with any dose of chemoradiotherapy as far as nonmarrow toxicity permitted, and then rescue them by marrow transplantation. Early clinical attempts were gen­ erally unsuccessful, mostly due to a lack of knowledge of histocompatibility antigens and appropriate supportive care. These areas developed rather quickly during the 1960s, and for almost two decades now clinical marrow transplan­ tation has been carried out with increasing success. After initially using only bone marrow from HLA indentical siblings, the field has expanded rapidly to incorporate HLA nonidentical related donors, and recently even marrow from unrelated volunteer donors. Furthermore, since for numerous patients who oth­ erwise could benefit from transplantation a donor cannot be identified, there has been a growing interest in using the patient’s own (autologous) bone marrow. Our understanding of the principles of transplantation and our knowledge of the potential risks and benefits have quickly grown. At times it is difficult, however, to decide what is the best option for a given patient.

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Reseña del editor

In the late 1940s investigators observed that mice given supralethai doses of total body irradiation were protected by infusion of viable spleen or marrow cells following irradiation, and that this was accomplished by hemopoietic reconsti­ tution with donor cells as proven using genetic markers. If a similar approach could be applied to humans, it should be possible to treat leukemia patients with any dose of chemoradiotherapy as far as nonmarrow toxicity permitted, and then rescue them by marrow transplantation. Early clinical attempts were gen­ erally unsuccessful, mostly due to a lack of knowledge of histocompatibility antigens and appropriate supportive care. These areas developed rather quickly during the 1960s, and for almost two decades now clinical marrow transplan­ tation has been carried out with increasing success. After initially using only bone marrow from HLA indentical siblings, the field has expanded rapidly to incorporate HLA nonidentical related donors, and recently even marrow from unrelated volunteer donors. Furthermore, since for numerous patients who oth­ erwise could benefit from transplantation a donor cannot be identified, there has been a growing interest in using the patient's own (autologous) bone marrow. Our understanding of the principles of transplantation and our knowledge of the potential risks and benefits have quickly grown. At times it is difficult, however, to decide what is the best option for a given patient.

Reseña del editor

This book provides a comprehensive survey of transplantation including pre-transplant considerations, the transplant procedure, acute and delayed transplant related problems, and an outlook on future developments. The authors have addressed the principles involved in marrow transplantation. Thus, this text should help practicing hematologists, oncologists and other physicians - as well as physicians in training and students - to develop an idea as to when bone marrow transplantation should be considered, what steps need to be taken to make it possible, what the costs are, how a donor can be selected, and so forth. It also reviews potential complications and side effects, aspects particularly useful for the physician who assumes the care of patients after their return from a transplant center. Knowledge of the various areas under discussion should allow smoother communication between primary care physicians and transplant physicians, thus optimizing the treatment approach for any individual patient.

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Verlag
Springer
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3642970796
ISBN 13 
9783642970795
Einband
Tapa blanda
Anzahl der Seiten
204
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Deutschland

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